Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — TP53

Text-mined interactions from Literome

Mueller et al., Circulation 2002 : Overexpression of antisense Id3 abrogated the effect of Ang II on the expression of p21 ( WAF1/Cip1 ), p27 ( Kip1 ), and p53
Min et al., Cardiovasc Res 2007 : Persistent Ang II ( 100 nM ) stimulation increased SA-beta-gal stained VSMC and enhanced expression of p21, p53 , p16, p27 and Ki-ras2A
Liu et al., Toxicol Lett 2009 : The present study was to investigate whether Ang II induces p53 expression and activation and if so, whether Ang II-induced cardiac cell death is p53 dependent, and whether a potent antioxidant metallothionein ( MT ) prevents Ang II-induced p53 expression, and associate apoptotic cell death signaling