Felmlee et al., Drug Metab Dispos 2008
:
In contrast, expression of CYP3A4 in transgenic mouse livers did not increase dextromethorphan N-demethylase and midazolam 1'-hydroxylase activities
Cribb et al., Drug Metab Dispos 1995
:
Antiserum from a rabbit ( # 236 ) immunized with peptide 2 inhibited up to 95 % of dextromethorphan O-demethylase activity in human liver microsomes at the highest concentration tested ( 40 % v/v ) but did not significantly inhibit CYP1A2, CYP2C9, CYP2E1, or CYP3A4 marker activities