Pai et al., Mol Biol Cell 2004
(Colonic Neoplasms...) :
Our results show that low concentrations of DCA ( 5 and 50 microM ) significantly increase tyrosine phosphorylation of beta-catenin , induce urokinase-type plasminogen activator, uPAR , and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness ... Inhibition of beta-catenin with small interfering RNA significantly reduced DCA induced uPAR and cyclin D1 expression
Mann et al., Proc Natl Acad Sci U S A 1999
(Adenocarcinoma...) :
Thus, accumulation of beta-catenin indirectly affects the expression of uPAR in vitro and in vivo