◀ Back to MAPK14
MAPK14 — MAPKAPK3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPKAPK3
→
MAPK14
(directlyIncreases, MAPKAPK3 Activity)
Evidence: exercise leads to the activation of at least three MAPK signalling pathways, i.e. ERK1/2, p38 MAPK and JNK, in skeletal muscle (Zierath, 2002).
-
KEGG VEGF signaling pathway:
MAPK11/MAPK12/MAPK13/MAPK14
→
MAPKAPK2/MAPKAPK3
(protein-protein, activation)
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KEGG MAPK signaling pathway:
MAPK11/MAPK12/MAPK13/MAPK14
→
MAPKAPK2/MAPKAPK3
(protein-protein, phosphorylation)
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NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
p38alpha-beta-active (MAPK14/MAPK11)
→
MAPKAPK3 (MAPKAPK3)
(modification, collaborate)
McLaughlin et al., J Biol Chem 1996*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
p38alpha-beta-active (MAPK14/MAPK11)
→
p38alpha-beta/MAPKAPK3 complex (MAPK14_MAPK11-MAPKAPK3)
(modification, collaborate)
McLaughlin et al., J Biol Chem 1996*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
MAPKAPK3 (MAPKAPK3)
→
p38alpha-beta/MAPKAPK3 complex (MAPK14_MAPK11-MAPKAPK3)
(modification, collaborate)
McLaughlin et al., J Biol Chem 1996*
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
MAPKAPK3
→
MAPK14
(direct_complex)
Meng et al., J Biol Chem 2002*, Lukas et al., Biochemistry 2004*, ter Haar et al., J Biol Chem 2007, White et al., Proc Natl Acad Sci U S A 2007*, Raingeaud et al., J Biol Chem 1995, Raingeaud et al., Mol Cell Biol 1996, Sithanandam et al., Mol Cell Biol 1996*, McLaughlin et al., J Biol Chem 1996*, Clifton et al., FEBS Lett 1996, Ben-Levy et al., EMBO J 1995*, Ben-Levy et al., Curr Biol 1998*
-
Reactome Reaction:
MAPKAPK3
→
MAPK14
(reaction)
Lukas et al., Biochemistry 2004*, ter Haar et al., J Biol Chem 2007, White et al., Proc Natl Acad Sci U S A 2007*, Sithanandam et al., Mol Cell Biol 1996*, McLaughlin et al., J Biol Chem 1996*, Clifton et al., FEBS Lett 1996, Ben-Levy et al., EMBO J 1995*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAPKAPK3
—
MAPK14
(physical association, affinity chromatography technology)
Varjosalo et al., Nat Methods 2013
-
IRef Biogrid Interaction:
MAPKAPK3
—
MAPK14
(direct interaction, pull down)
Tanoue et al., EMBO J 2001*
-
IRef Biogrid Interaction:
MAPKAPK3
—
MAPK14
(physical association, affinity chromatography technology)
Tanoue et al., EMBO J 2001*
-
IRef Hprd Interaction:
MAPK14
—
MAPKAPK3
(in vivo)
Tanoue et al., EMBO J 2001*
-
IRef Hprd Interaction:
MAPK14
—
MAPKAPK3
(in vitro)
Tanoue et al., EMBO J 2001*
-
IRef Innatedb Interaction:
MAPK14
—
MAPKAPK3
(unknown, -)
Gum et al., Biochem Biophys Res Commun 1999*
-
IRef Innatedb Interaction:
MAPK14
—
MAPKAPK3
(unknown, -)
Tanoue et al., EMBO J 2001*
-
IRef Innatedb Interaction:
MAPK14
—
MAPKAPK3
(unknown, -)
McLaughlin et al., J Biol Chem 1996*
-
IRef Intact Interaction:
Complex of 11 proteins
(association, tandem affinity purification)
Varjosalo et al., Cell reports 2013
-
IRef Intact Interaction:
Complex of 19 proteins
(association, tandem affinity purification)
Varjosalo et al., Cell reports 2013
-
IRef Intact Interaction:
Complex of MAPK14-MKNK1-MAPKAPK2-OBSL1-MAPKAPK3-CUL7-CCDC8
(association, tandem affinity purification)
Varjosalo et al., Nat Methods 2013
-
IRef Ophid Interaction:
MAPK14
—
MAPKAPK3
(aggregation, confirmational text mining)
Tanoue et al., EMBO J 2001*
-
IRef Ophid Interaction:
MAPK14
—
MAPKAPK3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pugazhenthi et al., J Biol Chem 1999
:
The dominant negative form of
MAPKAP-K3 , a downstream kinase activated by p38 MAPK, and the dominant negative form of cAMP-response element binding protein,
inhibited the reporter gene activation by IGF-I and p38beta
MAPK significantly ( p < 0.01 )
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Mitogen activated protein kinase and nuclear factor kappaB together regulate interleukin-17 induced nitric oxide production in human osteoarthritic chondrocytes : possible role of transactivating factor
mitogen activated protein kinase activated proten kinase (
MAPKAPK )
Dingar et al., Cell Signal 2010
(Cardiomegaly...) :
Whereas MK2 and
MK3 are
activated by p38
MAPK , MK5 has also been shown to be activated by ERK3 and ERK4
Sithanandam et al., Mol Cell Biol 1996
(Carcinoma, Small Cell...) :
3pK , a new
mitogen activated protein kinase activated protein kinase located in the small cell lung cancer tumor suppressor gene region
Komatsu et al., Arch Biochem Biophys 1997
:
The protein kinase activity of
GST-MAPKAPK-4 was
activated by
MAPK and this enabled the kinase to phosphorylate both glycogen synthase N-terminal peptide and the regulatory light chain of myosin II in vitro