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PTBP2 — RELA
Text-mined interactions from Literome
Ruby et al., Mol Pharmacol 2002
:
Dendritic cells (DCs) , considered to be the `` pacemakers '' of the immune system, were recently recognized as targets of TCDD and are also
dependent on
NF-kappaB/Rel for activation and survival
Hu et al., Infect Immun 2006
:
In addition, Campylobacter infected
DCs triggered activation of
NF-kappaB and significantly stimulated production of interleukin-1beta (IL-1beta), IL-6, IL-8, IL-10, IL-12, gamma interferon, and tumor necrosis factor alpha (TNF-alpha) compared to uninfected DCs
Golks et al., J Exp Med 2006
(Neoplasms) :
Here, we demonstrate that the cytoplasmic NH2-terminal procaspase-8 cleavage product of c-FLIP ( p22-FLIP ) found in nonapoptotic malignant cells, primary T and B cells, and mature
dendritic cells (DCs) strongly
induces nuclear factor kappaB (NF-kappaB) activity by interacting with the IkappaB kinase (IKK) complex via the IKKgamma subunit
Xu et al., J Biol Chem 2009
(Calcium Signaling) :
In addition, PLCgamma2-deficient
DCs are also
impaired in their activation of
NF-kappaB upon Dectin-1 engagement due to defective assembly of the Card9-Bcl10-Malt1 complex and impaired IKKalpha/beta activation and IkappaBalpha degradation
Zhu et al., J Interferon Cytokine Res 2009
:
DCs treated with HMGB1 ( 1 microg/mL for 48 h ) promoted T-cell proliferation as well as differentiation, and markedly
up-regulated IL-2, IL-2R expression and intranuclear
NF-kappaB activation
Bansal et al., J Immunol 2010
(Tuberculosis) :
We further found that PE_PGRS protein mediated activation of
DCs involves participation of ERK1/2, p38 MAPK, and
NF-kappaB signaling pathways
Yekollu et al., Diabetes 2011
(Insulin Resistance...) :
Targeting
Tip-DCs and ATMs with curcusomes in ob/ob mice
reduced NF-?B/RelA DNA binding activity, reduced TNF, and enhanced interleukin-4 production