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RET — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SRC → RET (increases, RET Activity, SRC Translocation)
  Evidence: The GPI anchor localizes GFR-a to lipid rafts. GDNF binding to GFR-a recruits RET to lipid rafts, thereby facilitating RET interaction with the c-Src kinase and the FRS2 docking protein.
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Src (SRC) (modification, collaborate) Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Src (SRC) → RET51/GFRalpha1/GDNF/Dok6 complex (RET-DOK6-GFRA1-GDNF) (modification, activates)
  Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — RET (physical association, affinity chromatography technology) Melillo et al., Cancer Res 1999*
• IRef Hprd Interaction: SRC — RET (in vivo) Melillo et al., Cancer Res 1999*
• IRef Ophid Interaction: SRC — RET (aggregation, confirmational text mining) Melillo et al., Cancer Res 1999*
• IRef Ophid Interaction: SRC — RET (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Melillo et al., Cancer Res 1999 : Ret stimulation resulted in the activation of c-Src ... These experiments demonstrate that activated Ret is able to bind and stimulate c-Src kinase and that Src activation is essential for the mitogenic activity of Ret
Cao et al., Glia 2006 (Disease Models, Animal...) : GDNF induced OECs migration was demonstrated depending on GFRalpha-1 and Ret receptor, and activation of JNK and Src signaling cascades