◀ Back to IL6

IL6 — MMP1

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Shibata et al., Angiology 1999 (Angina Pectoris...) : The increased IL-6 production may induce MMP-1 , leading to tissue organ injury
Bondeson et al., J Rheumatol 2000 (Arthritis, Rheumatoid...) : To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6 , 8, and 11 and matrix metalloproteinases (MMP)-1 , 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB)
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha, IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Irwin et al., J Periodontol 2002 (Periodontal Diseases) : The role of soluble interleukin (IL)-6 receptor in mediating the effects of IL-6 on matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts ... This study investigated the effects of IL-6 on matrix metalloproteinase (MMP)-1 activity in gingival fibroblast cultures, specifically determining the role of the sIL-6r in mediating these actions
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6 , though the mechanisms were not clear
Ray et al., Arthritis Rheum 2003 (Osteoarthritis) : Overexpression of SAF-1 in OA chondrocytes increased the expression of the MMP1 promoter, and interference of endogenous SAF-1 activity by antisense SAF-1 messenger RNA inhibited interleukin-1 mediated MMP1 promoter activity
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6 , HGF, and 12-O-tetradecanoylphorbol 13-acetate
Dasu et al., Burns Incl Therm Inj 2003 : MMP-1 and TIMP-1 mRNA expression were markedly increased with IL-6 and TNF-alpha treatment and remains unchanged with IL-1beta
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Kim et al., Arch Pharm Res 2004 : Compound 3 suppressed the expression of MMP-1 by up to 44 % at 4.0 microM and inhibited the production of interleukin 6 (IL-6) , which is known as a cytokine that induces MMP-1 expression
Park et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : The specific inhibition of IL-6 using a monoclonal antibody against IL-6 greatly reduced the expression of MMP-1 and MMP-3 induced by heat shock
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP
Sundelin et al., Acta Otolaryngol 2005 (Carcinoma, Squamous Cell...) : The objective of this study was to investigate the effects of IL-6 , soluble IL-6 receptor ( sIL-6R ), HGF, TNF-a and IL-8 on MMP-1 , -2 and -9 expression by two oral squamous cell carcinoma cell lines ( UT-SCC-20A and -24A )
Previti et al., Journal of neuroinflammation 2006 : Our results suggest that although dexamethasone has no appreciable consequence on HCSM cell surface fibrillar Abeta accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6 , MMP-2 activation , and depletion of HCSM alpha actin
Abe et al., Cell Tissue Res 2008 : In contrast, the decreased production of MMP-1 was restored at 0.1-100 ng/ml CyA in the presence of IL-6
Sundararaj et al., J Biol Chem 2009 : Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture : cross talking between fibroblasts and U937 macrophages exposed to high glucose ... We also found that interleukin 6 (IL-6) released by fibroblasts was essential for the augmentation of MMP-1 expression by U937 macrophages ... Furthermore our results showed that high glucose, IL-6 , and lipopolysaccharide had a synergistic effect on MMP-1 expression ... In conclusion, this study demonstrates that IL-6 derived from fibroblasts is essential for MMP-1 up-regulation by cross talking between fibroblasts and U937 macrophages exposed to high glucose, revealing an IL-6 dependent mechanism in MMP-1 up-regulation
Li et al., J Cell Biochem 2010 (MAP Kinase Signaling System) : Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine, it remains unclear how IL-6 regulates MMP expression by mononuclear phagocytes ... Furthermore, it remains undetermined how IL-6 in combination with hyperglycemia affects MMP expression ... In the present study, we investigated the regulatory effect of IL-6 alone or in combination with high glucose on MMP-1 expression by U937 mononuclear phagocytes ... We found that IL-6 is a powerful stimulator for MMP-1 expression and high glucose further augmented IL-6 stimulated MMP-1 expression ... We also found that high glucose, IL-6 , and lipopolysaccharide act in concert to stimulate MMP-1 expression ... In the studies to elucidate underlying mechanisms, the extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) pathways were found to be required for stimulation of MMP-1 by IL-6 and high glucose ... Finally, we demonstrated that similarly to U937 mononuclear phagocytes, IL-6 and high glucose also stimulated MMP-1 secretion from human primary monocytes ... In conclusion, this study demonstrated that IL-6 and high glucose synergistically stimulated MMP-1 expression in mononuclear phagocytes via ERK and JNK cascades and c-Jun upregulation
Abe et al., J Nat Prod 2010 : The effects of these new compounds on interleukin-1ß induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Nakamura-Shibasaki et al., Cell Biochem Funct 2013 : Depletion of IL-6 by RNA interference in cells isolated after filtration surgery increased the expression of MMP-1 and MMP-3 in these cells ... These results thus suggest that the expression of MMP-1 and MMP-3 in Tenon fibroblasts is regulated by IL-6 during, and may play an important role in, scar formation after glaucoma surgery
Gotoh et al., Connect Tissue Res 2013 : Extracellular ß-NAD ( + ) inhibits interleukin-1 induced matrix metalloproteinase-1 and -3 expression on human gingival fibroblasts
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6 , and interferon-gamma had no consistent effect on MMP production
Wlaschek et al., Photochem Photobiol 1994 : From these data we suggest a UV-induced cytokine network consisting of IL-1 alpha, IL-1 beta and IL-6 , which via interrelated autocrine loops induce collagenase/MMP-1 and thus may contribute to the loss of interstitial collagen in cutaneous photoaging
Richards et al., J Immunol 1993 (Neoplasms) : The results suggest that OM as well as IL-6 and LIF, other cytokines acting through similar receptor pathways, may act to inhibit net MMP activity by specifically up-regulating TIMP-1 expression
Langdon et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1 induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro
Dean et al., J Biol Chem 1999 : We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts