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CASP6 — POLDIP2
Text-mined interactions from Literome
Harada et al., Jpn J Pharmacol 1999
:
These results suggest that activation of c-Jun by
p38 and/or JNK
mediates the activation of
caspase in the low KCl induced apoptosis in cerebellar granule neurons
Fecteau et al., J Pharmacol Exp Ther 2002
(Cell Transformation, Neoplastic) :
Induction of apoptosis of ras transformed cells by FR901228 correlates with suppression of the extracellular signal regulated kinase ( ERK ) signaling pathway through reduction of Raf expression and deactivation of Mek and Erk, inhibition of the phosphoinositide-3 kinase (PI3-K) pathway indexed by suppression of Akt activity, suppression of
p38 activity, and
activation of
caspase-3
Choi et al., J Biol Chem 2004
:
Following 6-hydroxydopamine treatment, inhibition of
p38 prevented both
caspase-8- and -9-mediated apoptotic pathways as well as generation of truncated Bid
Kwon et al., Life Sci 2007
:
IL-1 beta release and
caspase-1 activity induced by DSS were significantly
inhibited by a MAPK kinase 1/2 inhibitor, a
p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor
Yoon et al., Mol Cancer Res 2009
(MAP Kinase Signaling System) :
In this study, we show that sphingosine induces death receptor independent
caspase-8 activation and apoptotic cell death via p38 mitogen activated protein kinase ( MAPK ) activation and that suppression of the MAPK/extracellular signal regulated kinase ( ERK ) kinase/ERK pathway by protein phosphatase 2A (PP2A) is
required for
p38 MAPK activation
Yadav et al., Free Radic Biol Med 2010
:
Benfotiamine prevented LPS induced apoptosis, expression of the Bcl-2 family of proapoptotic proteins,
caspase-3 activation , and PARP cleavage and altered mitochondrial membrane potential and release of cytochrome c and apoptosis inducing factor and phosphorylation and subsequent activation of
p38-MAPK , stress activated kinases ( SAPK/JNK ), protein kinase C, and cytoplasmic phospholipase A2 in RAW cells
Brama et al., J Endocrinol Invest 2012
(MAP Kinase Signaling System...) :
In conclusion, at least 2 pathways appear activated by cadmium in osteoblasts : a direct induction of caspase-8 followed by activation of
caspase-3 and an indirect
induction by phosphorylation of ERK1/2,
p38 , and JNK MAPK triggering activation of caspase-8 and -3