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EGR1 — HGF

Text-mined interactions from Literome

Houston et al., Biochem Biophys Res Commun 2001 : NAB2 blocks Egr-1 activation of the tissue factor ( TF ) promoter, Egr-1 stimulated production of PDGF-AB, HGF , TGFbeta(1), and VEGF and the endogenous expression of PDGF-AB and TGFbeta(1)
Day et al., J Biol Chem 2004 : Immunocytochemistry and electrophoretic mobility shift assay showed that both HGF and PMA increased Egr-1 binding ... However, HGF and PMA increased the cellular activity of only Egr-1 , not SP3, as measured by luciferase reporter assays
Gaggioli et al., Oncogene 2005 (MAP Kinase Signaling System...) : HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase dependent signaling pathway and induction of Egr-1 ... Inhibition of B-RAF/MAP kinase pathway by dominant negative mutants and by U0126 abrogated HGF induced Egr-1, and chromatin immunoprecipitation showed that Egr-1 is bound to the fibronectin promoter in response to HGF
Worden et al., Cancer Res 2005 (Carcinoma, Squamous Cell...) : In the present study, we investigated the potential role of HGF induced Egr-1 in expression of PDGF, VEGF, and IL-8 ... HGF induced expression of all three factors and Egr-1 expression and DNA binding activity ... HGF induced expression of Egr-1 , PDGFA, and VEGF was suppressed by pharmacologic and siRNA inhibitors of mitogen activated protein kinase kinase 1/2 ( MEK1/2 ) and protein kinase C ( PKC ) pathways ... We conclude that the HGF induced activation of transcription factor Egr-1 by MEK1/2- and PKC dependent mechanisms differentially contributes to expression of PDGF and VEGF, which are important angiogenesis factors and targets for HNSCC therapy
Lee et al., Clin Exp Metastasis 2009 (Carcinoma, Hepatocellular...) : Egr-1 knockdown reduced the luciferase activities increased by HGF not in the IL-8 promoter, but in the VEGF promoter