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MAT2A — TNF

Text-mined interactions from Literome

Yang et al., J Biol Chem 2003 (Carcinoma, Hepatocellular) : Tumor necrosis factor alpha (TNFalpha) , which activates both NF-kappa B and AP-1, increased MAT2A expression in a dose- and time dependent manner, binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity, with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites ... Blocking NF-kappa B with I kappa B super-repressor or AP-1 with dominant negative c-Jun led to decreased basal MAT2A expression and prevented the TNF alpha induced increase in MAT2A expression
Kino et al., J Allergy Clin Immunol 2007 : TB-2-081, and to a lesser extent TB-2-082, suppressed IL-6 induced alpha1-antichymotrypsin (AACT) mRNA expression in HepG2 cells, whereas TB-2-081 failed to influence the mRNA expression of the TNF-alpha induced mRNA expression of the methionine adenosyltransferase 2A gene in these cells