◀ Back to NFKB1
NFKB1 — NOX4
Text-mined interactions from Literome
Bonizzi et al., Mol Cell Biol 1999
(Adenocarcinoma) :
Reactive oxygen intermediate dependent
NF-kappaB activation by interleukin-1beta
requires 5-lipoxygenase or
NADPH oxidase activity
Yoshida et al., J Immunol 2001
:
Inhibition of
NADPH oxidase suppressed
NF-kappaB binding by nuclear extracts and decreased production of MMP-2 and 9 in AMs from SP-D ( -/- ) mice
Brar et al., Am J Physiol Lung Cell Mol Physiol 2002
:
NADPH oxidase promotes
NF-kappaB activation and proliferation in human airway smooth muscle ... Inhibition of
NADPH oxidase activity with DPI
prevented serum induced activation of nuclear factor-kappaB
(NF-kappaB) , and overexpression of a superrepressor form of the NF-kappaB inhibitor IkappaBalpha significantly reduced human AWSM growth
Aramaki et al., Biol Pharm Bull 2002
:
These results indicated that
NADPH-oxidase plays a crucial role in macrophage activation by CpG-ODN and
NF-kappaB does not act as a predominant transcription factor for IL-12 secretion
Fass et al., Brain Res 2004
:
To determine whether different types of NO donors exert differential toxicity in a cholinergic neuronal model, we measured cell viability markers, indicators of
NOx formation, levels of intracellular reduced glutathione ( GSH ), protein nitrosothiols, and the
activation of the transcription factor
NF-kappaB in a mouse medial septal cholinergic cell line ( clone SN56 ) following exposure to the NO donors S-nitroso-N-acetyl-dl-penicillamine ( SNAP ), 3-morpholinosydnonimine ( SIN-1 ), or sodium nitroprusside ( SNP )
Yamagishi et al., J Mol Cell Cardiol 2004
:
The results demonstrated that PEDF
inhibited TNF-alpha induced
NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing
NADPH oxidase mediated ROS generation
Beak et al., Biochimie 2004
:
These results suggest that the
NADPH oxidase and COX may be major sources for the UVB induced ROS generation, and
play an essential role in the activation of
NF-kappaB which is involved in the expression of a variety of genes induced by UVB in HaCaT cells
Park et al., J Immunol 2004
:
In this study, we present the data that LPS induced ROS generation and
NF-kappaB activation are
mediated by a direct interaction of TLR4 with (
NAD(P)H oxidase 4 ( Nox) 4 ), a protein related to gp91phox ( Nox2 ) of phagocytic cells, in HEK293T cells
Yu et al., Int J Biochem Cell Biol 2005
:
NADPH oxidase inhibitor diphenylene iodonium ( DPI ), antioxidant rebamipide, and antisense oligonucleotides ( AS ODNs ) for NADPH oxidase subunits p22phox and p47phox were used to determine the
involvement of
NADPH oxidase in
NF-kappaB activation and IL-6 expression in AR42J cells
Anrather et al., J Biol Chem 2006
:
NF-kappaB regulates phagocytic
NADPH oxidase by inducing the expression of gp91phox
Frey et al., J Biol Chem 2006
:
Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces
NADPH oxidase mediated oxidant generation and
NF-kappaB activation in endothelial cells ... Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling
NADPH oxidase dependent oxidant production and subsequent
NF-kappaB activation and ICAM-1 expression
LemariƩ et al., Circ Res 2006
:
Here we report that high intraluminal pressure induces reactive oxygen species ( ROS ) in arteries and that inhibition of
NADPH oxidase prevents both the generation of ROS and the activation of
NF-kappaB associated with high pressure
Takenaka et al., J Mol Cell Cardiol 2006
(Heart Failure...) :
Local activation of Ang-II in hypertrophic LV triggers MMP mediated ECM degradation, namely LV remodeling, at least in part, through
NADPH oxidase induced oxidative stress and the subsequent
NFkappaB activation
Jo et al., Antioxid Redox Signal 2006
(Atherosclerosis...) :
The
NADPH oxidase activation by BMP4 then
leads to ROS production,
NF-kappaB activation, intercellular adhesion molecule 1 ( ICAM-1 ) expression, and subsequent increased monocyte adhesivity of endothelial cells
Dasu et al., Am J Physiol Endocrinol Metab 2007
(MAP Kinase Signaling System) :
At the same time, it appears that
NADPH oxidase via p47phox
activates NF-kappaB , resulting in increased IL-1beta secretion
Gauss et al., J Leukoc Biol 2007
:
Role of
NF-kappaB in transcriptional regulation of the phagocyte
NADPH oxidase by tumor necrosis factor-alpha
Carluccio et al., Am J Physiol Heart Circ Physiol 2007
(Hyperhomocysteinemia) :
Homocysteine
induces VCAM-1 gene expression through
NF-kappaB and
NAD ( P ) H oxidase activation : protective role of Mediterranean diet polyphenolic antioxidants
Chan et al., J Pharmacol Exp Ther 2007
(Acute Disease...) :
These data provide substantial evidence that angiotensin II is involved in AT1 receptor mediated
NADPH oxidase dependent
NF-kappaB activation ; thus, it might ultimately promote proinflammatory actions during AP pathogenesis
Vaziri et al., J Pharmacol Exp Ther 2007
(Disease Models, Animal...) :
The untreated group exhibited hypertension, deterioration of renal function and structure, reduced or unchanged plasma renin activity, aldosterone concentration, marked up-regulations of AT1r ( 250 % ), Ang II-expressing cell count ( > 20-fold ),
NAD ( P ) H oxidase subunits ( gp91(phox,) p22(phox), and P47 ( phox ) ; 20-40 % ), COX-2 ( 250 % ), 12-lipooxygenase ( 100 % ), MCP-1 ( 400 % ), and PAI-1 ( > 20-fold ),
activation of
NFkappaB , and interstitial infiltrations of T cells and macrophages in the remnant kidneys
Kim et al., J Ethnopharmacol 2007
:
Furthermore, macrophages stimulated with LPS generated ROS via activation of membrane bound
NADPH oxidase , and ROS
played an important role in the activation of
nuclear factor-kappaB (NF-kappaB) and MAPKs
Wei et al., Am J Physiol Endocrinol Metab 2008
(Insulin Resistance) :
Angiotensin II-induced skeletal muscle insulin resistance mediated by
NF-kappaB activation via
NADPH oxidase
Manea et al., Arch Physiol Biochem 2007
:
Here we investigate the
role of
NF-kB in the regulation of p22(phox) subunit and
NADPH oxidase activity, in human aortic smooth muscle cells ...
Regulation of
NADPH oxidase by
NF-kB may represent a possible mechanism whereby pro-inflammatory factors induce oxidative stress in atherosclerosis, hypertension, diabetes, stroke or heart failure
Luengo-Blanco et al., Blood 2008
(Ectodermal Dysplasia...) :
This work investigated the functional
role of
nuclear factor-kappaB (NF-kappaB) in respiratory burst activity and in expression of the human phagocyte nicotinamide adenine dinucleotide phosphate (
NADPH ) oxidase genes CYBB, CYBA, NCF1, and NCF2 ... These studies show that
NF-kappaB is
necessary for CYBB and NCF1 gene expression and activation of the phagocyte
NADPH oxidase in this model system
Guo et al., Antioxid Redox Signal 2008
(MAP Kinase Signaling System...) :
Incubation of AOPPs, either prepared in vitro or isolated from uremic serum, with human umbilical vein ECs induced superoxide generation,
activation of
NAD ( P ) H oxidase , ERK 1/2 and p38, and nuclear translocation of
NF-kappaB
Collins-Underwood et al., Free Radic Biol Med 2008
:
We report that irradiating rat brain microvascular endothelial cells in vitro leads to increased ( i ) intracellular ROS generation, ( ii )
activation of the transcription factor
NFkappaB , ( iii ) expression of ICAM-1 and PAI-1, and ( iv ) expression of
Nox4 , p22(phox), and p47(phox) ... Pharmacologic and genetic inhibition of
NADPH oxidase blocked the radiation mediated upregulation of intracellular ROS, activation of
NFkappaB , and upregulation of ICAM-1 and PAI-1
Bai et al., Am J Nephrol 2009
(Kidney Failure, Chronic...) :
Voluntary exercise reversed
NF-kappaB activation and lowered
NAD ( P ) H oxidase , PAI-1, MCP-1 and COX-2 abundance,
increased LV mass by raising myofibrillar proteins and ameliorated anemia without affecting renal function or arterial pressure
Zhang et al., Invest Ophthalmol Vis Sci 2009
(Diabetes Mellitus, Experimental...) :
Analysis of downstream signals showed that inhibition of
NAD ( P ) H oxidase partially
inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent TNF-alpha induced phosphorylation of p38MAPK
Cho et al., American journal of physiology. Renal physiology 2009
(Disease Models, Animal...) :
The untreated CKD rats exhibited azotemia, hypertension, hypertriglyceridemia, proteinuria, glomerulosclerosis, tubulointerstitial damage, upregulation of MCP-1, plasminogen activator inhibitor-1 ( PAI-1 ), transforming growth factor ( TGF ) -beta, cyclooxygenase (COX)-1, COX-2, and
NAD ( P ) H oxidase ( NOX-4, gp91(phox), p47(phox) and p22(phox) subunits ) and
activation of
NF-kappaB ( IkappaB phosphorylation )
Pan et al., Braz J Med Biol Res 2009
(Inflammation) :
These data suggest that the inhibition of
NAD ( P ) H oxidase dependent
NF-kappaB signaling reduces the increase in MCP-1 production by GECs induced by Ang II
Maloney et al., Arterioscler Thromb Vasc Biol 2009
:
Activation of
NF-kappaB by palmitate in endothelial cells : a key role for
NADPH oxidase derived superoxide in response to TLR4 activation
Kim et al., American journal of physiology. Renal physiology 2010
(Disease Models, Animal...) :
In confirmation of earlier studies, rats with chronic renal failure exhibited increased lipid peroxidation, glutathione depletion,
NF-kappaB activation , mononuclear cell infiltration, and upregulation of monocyte chemoattractant protein-1,
NAD ( P ) H oxidase , cyclooxygenase-2, and 12-lipoxygenase in the remnant kidney pointing to oxidative stress and inflammation
Wang et al., Circ Res 2010
:
Consistently, we found that genetic deletion of AMPKalpha2 in low-density lipoprotein receptor knockout ( LDLr ( -/- ) ) strain markedly increased 26S proteasome activity, IkappaB degradation,
NF-kappaB transactivation ,
NAD ( P ) H oxidase subunit overexpression, oxidative stress, and endothelial dysfunction, all of which were largely suppressed by chronic administration of MG132, a potent cell permeable proteasome inhibitor
Heo et al., Vascul Pharmacol 2010
(Atherosclerosis) :
Furthermore, the
NADPH oxidase assembly inhibitor, AEBSF, and the blocker of NADPH oxidase, p47(phox) small interference RNA ( siRNA ), also efficiently
blocked LIGHT induced migration, CCR1, CCR2, ICAM-1, and HVEM expression, and p38 MAPK and
NF-kB activation
Manea et al., Biochem Biophys Res Commun 2010
(Atherosclerosis...) :
Since nuclear factor-kappaB (NF-kappaB) controls the expression of many genes associated to inflammation related diseases, in this study we have investigated the
role of
NF-kappaB signaling in the regulation of Nox1 and
Nox4 transcription in human aortic smooth muscle cells ( SMCs )
Salzman et al., Gastroenterology 1998
(Salmonella Infections) :
In DLD-1 cells, S. dublin mediated
NOx was
blocked by inhibitors of
nuclear factor kappa B (NF-kappa B) and tyrosine kinase activation and was steroid resistant