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GRP — MAPK1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK1
→
GRP
(increases, GRP Activity)
Thomas et al., Neoplasia (New York, N.Y.) 2005*
Evidence: GRP induced rapid activation of p44/42 MAPK in lung cancer cells through EGFR.
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OpenBEL Selventa BEL large corpus:
MAPK1
→
GRP
(increases, GRP Activity, MAPK1 Activity)
Xiao et al., Cell Signal 2003*
Evidence: bombesin specifically induced mitogen-activated protein (MAP) kinase activation as shown by increased extracellular regulated kinase (ERK) phosphorylation and epidermal growth factor (EGF) receptor transactivation in prostate cancer cells, which express functional gastrin-releasing peptide receptor
Text-mined interactions from Literome
Lui et al., Oncogene 2003
(Carcinoma, Squamous Cell...) :
In HNSCC cells that express elevated levels of both GRPR and EGFR, we found that
GRP induced rapid phosphorylation of EGFR as well as
p44/42-MAPK activation ... Using several EGFR-specific tyrosine kinase inhibitors and cells derived from EGFR knockout mice, we demonstrated that
GRP induced
p44/42-MAPK activation was dependent upon EGFR activation ... Further investigation demonstrated that cleavage of transforming growth factor-alpha ( TGF-alpha ) by matrix metalloproteinases mediated
GRP induced
MAPK activation
Zhang et al., Cancer Res 2004
(Carcinoma, Squamous Cell...) :
Blockade of Src family kinases using an Src-specific tyrosine kinase inhibitor A-419259 decreased
GRP induced EGFR phosphorylation and
MAPK activation
Thomas et al., Neoplasia (New York, N.Y.) 2005
(Carcinoma, Non-Small-Cell Lung...) :
GRP induced rapid activation of p44/42
MAPK in lung cancer cells through EGFR ...
GRP mediated activation of
MAPK in NSCLC cells was abrogated by pretreatment with the anti-EGFR neutralizing antibody, C225 ... Pretreatment of NSCLC cells with neutralizing antibodies to the EGFR ligands, TGF-A or HB-EGF, also decreased
GRP mediated
MAPK activation
Li et al., Oncol Rep 2010
(Carcinoma, Hepatocellular...) :
GRP activated
MAPK/ERK1/2 in HepG2 cells, leading to enhanced proliferation, reduced apoptosis and accelerated cell cycle progression ...
GRP promotes the growth of HepG2 cells through interaction with GRPR co-expressed in tumor cells, and subsequently
activates MAPK/ERK1/2 via EGFR independent mechanisms
Sharif et al., Mol Cell Endocrinol 1997
(Glioblastoma) :
Stimulation of the glioblastoma cell line U-373MG with bombesin or
gastrin releasing peptide (GRP) induced mitogenesis, measured by [ 3H ] thymidine incorporation into DNA, and
stimulated the tyrosine phosphorylation of the
mitogen activated protein ( MAP ) kinases ( Erk1 and Erk2 )