◀ Back to RPL5
RPL5 — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TP53
→
RPL5
(increases, RPL5 Activity, TP53 Activity)
Dai et al., J Biol Chem 2004
Evidence: Here we have shown that L5 also activates p53. Consequently, L5 enhanced p53 transcriptional activity and induced p53-dependent G1 cell cycle arrest.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RPL5
—
TP53
(physical association, affinity chromatography technology)
Bursać et al., Proc Natl Acad Sci U S A 2012
-
IRef Biogrid Interaction:
RPL5
—
TP53
(physical association, affinity chromatography technology)
Dai et al., J Biol Chem 2004
-
IRef Hprd Interaction:
Complex of RPL5-TP53-MDM2-RPL5-TP53-TP53-MDM2-RPL5-MDM2
(in vivo)
Marechal et al., Mol Cell Biol 1994*
-
IRef Intact Interaction:
Complex of 244 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
Complex of 50 proteins
(association, anti tag coimmunoprecipitation)
Coffill et al., EMBO Rep 2012
-
IRef Ophid Interaction:
TP53
—
RPL5
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lindström et al., PloS one 2010
(Brain Neoplasms...) :
In these settings,
RPL11 was critical for maintaining p53 protein stability but was not strictly
required for
p53 protein synthesis
Sun et al., J Biol Chem 2010
:
Perturbation of
60 S ribosomal biogenesis
results in ribosomal protein L5- and L11 dependent
p53 activation
Golomb et al., Mol Cell 2012
:
Furthermore,
p53 activation is
dependent on
RPL5 and RPL11