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IFNG — LANCL1

Text-mined interactions from Literome

Haskó et al., Immunology 2001 : Sulphasalazine inhibited the LPS/IFN-gamma induced production of both interleukin-12 (IL-12) p40 and p70
Kopp et al., J Invest Dermatol 2001 (Disease Models, Animal...) : As induction of interferon-gamma is a major function of interleukin-12, we tested the in vitro ability of transgenic p40 to induce interferon-gamma
Padigel et al., J Immunol 2001 (Leishmaniasis, Cutaneous) : At wk 9 of infection, we detected similar levels of IL-4, IFN-gamma , IL-12p40, and IL-12Rbeta2 mRNA in draining lymph nodes of healing C57BL/6, CD28 ( -/- ), and CD40L ( -/- ) CD28 ( -/- ) mice, whereas CD40L ( -/- ) mice had increased mRNA levels for IL-4 but reduced levels for IFN-gamma, IL-12p40 , and IL-12Rbeta2
Haskó et al., J Pharmacol Exp Ther 2002 : In the current study, we investigated the involvement of ABC transporters in the regulation of lipopolysaccharide (LPS) and/or interferon (IFN)-gamma induced interleukin (IL)-12 p40 and tumor necrosis factor (TNF)-alpha production, nitric oxide formation, as well as major histocompatibility complex II up-regulation in macrophages
Petro et al., Int Immunopharmacol 2003 : Expression of p35 and p40 in response to lipopolysaccharide (LPS) and interferon (IFN)-gamma requires activation of nuclear factor-kappa-B (NF-kappaB) and interferon regulatory factor ( IRF ) transcription factors
Zhu et al., J Biol Chem 2003 : However, molecular mechanisms through which interferon (IFN)-gamma and bacterial products synergistically activate IL-12 p40 gene expression are less clear
Lew et al., Br J Dermatol 2004 (Disease Progression...) : The mRNA expression of keratin 16, CD25, IFN-gamma, IL-12 p40 , signal transducer and activator of transcription-1, inducible nitric oxide synthase, IL-8, macrophage inflammatory protein-3alpha, monocyte chemoattractant protein-1, S100A12, IFN-gamma-inducible protein of 10 kDa, IFN-inducible T-cell alpha-chemoattractant and monokine induced by IFN-gamma was increased in the lesions of both LP psoriasis and SP psoriasis
Nakahara et al., Clin Exp Immunol 2005 (Neoplasms) : However, IL-1beta, but not IFN-gamma , induced IL-12 p40 production by DCs without enhancing phenotypic maturation
An et al., Inflammation 2004 : In this study, using mouse peritoneal macrophages, we have examined whether XF affects nitric oxide ( NO ), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-12p40 production induced by interferon (IFN)-gamma and lipopolysaccharide (LPS)
Wheeler et al., Immunology 2006 (Encephalomyelitis, Autoimmune, Experimental) : There was greater expression of IL-12/23p40 by antigen presenting cells in these mice, and in vitro, TNFR1-/- antigen presenting cells induced greater secretion of IFN-gamma but not interleukin (IL)-17 when cultured with primed T cells than did WT antigen presenting cells
Nakano et al., Blood 2007 (Bacterial Infections...) : The transcription levels of p35 and p40 were increased by stimulation of BMMCs with IFN-gamma/lipopolysaccharide (LPS)
Qi et al., Sci China C Life Sci 2000 : Promoting effect of IFN-gamma on the expression of LPS induced IL-12 p40 and p35 mRNA in murine suppressor macrophages ... It was found that IFN-gamma strongly enhanced the LPS induced IL-12 p40 and p35 mRNA expression ... Taken together, the data suggest : ( i ) IFN-gamma/LPS could strongly induce the expression of IL-12 p40 and p35 mRNA ; both the expression levels were equal ; this phenomenon coincided with the high-level secretion of IL-12 p70 induced by IFN-gamma/LPS ; ( ii ) NF-kappaB signal pathway is essential for IFN-gamma/LPS to induce IL-12 mRNA expression ; ( iii ) by blocking the degradation of IkappaB, the PSI suppresses the IL-12 p40/p35 mRNA expression induced by LPS and IFN-gamma/LPS ; ( iv ) NF-kappaB signal may not be involved in the mechanism by which IFN-gamma enhanced the expression of the LPS induced IL-12 p40/p35 mRNA
Hayes et al., Blood 1995 : Time course experiments demonstrated independent regulation of p40 and p35 by IFN-gamma and LPS
Gillessen et al., Eur J Immunol 1995 : The ( p40 ) 2 was 25- to 50-fold more active than the p40 monomer in causing specific, dose dependent inhibition of IL-12 induced mouse concanavalin A ( Con A ) blast proliferation and could also inhibit IL-12 induced interferon-gamma (IFN-gamma) secretion by mouse splenocytes and IL-12 dependent activation of mouse NK cells
Mattner et al., Eur J Immunol 1993 : Furthermore, the synthesis of interferon (IFN)-gamma by mouse splenocytes activated with IL-2 and IL-12 was suppressed by IL-12p40
Piccotti et al., J Immunol 1997 : To determine which T cell population produced enhanced levels of IFN-gamma in response to p40 homodimer, CD4+ or CD8+ T cells were depleted from the MLC
Isler et al., Am J Respir Cell Mol Biol 1999 : Both p35 and p40 mRNA levels were induced by lipopolysaccharide (LPS) and were further increased by interferon-gamma (IFN-gamma)