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IL6 — PDGFB

Text-mined interactions from Literome

Franchimont et al., J Biol Chem 1999 : Platelet derived growth factor (PDGF) BB , a mitogen that stimulates bone resorption, increases the expression of interleukin-6 (IL-6) , a cytokine that induces osteoclast recruitment ... The mechanisms involved in IL-6 induction by PDGF BB are poorly understood ... We examined the effect of PDGF BB on IL-6 expression in cultures of osteoblasts from fetal rat calvariae ( Ob cells ) ... Targeted mutations of a cyclic AMP-responsive element ( CRE ), and nuclear factor-IL-6 and nuclear factor-kappaB binding sites in a bp -257 to +20 IL-6 construct that was transfected into Ob cells, revealed that the CRE also contributed to IL-6 promoter induction by PDGF BB ... In conclusion, PDGF BB induces IL-6 transcription in osteoblasts by regulating nuclear proteins of the AP-1 complex and activating transcription factor-2
Liu et al., J Biol Chem 2004 : PDGF-BB and thrombin also induced interleukin-6 (IL-6) expression in NFAT dependent manner
Masamune et al., Biochem Pharmacol 2005 : Ellagic acid inhibited platelet derived growth factor (PDGF)-BB induced proliferation and migration, interleukin (IL)-1beta- and tumor necrosis factor (TNF)-alpha induced monocyte chemoattractant protein-1 production, and expression of alpha-smooth muscle actin and collagen genes
Hanai et al., J Cell Biochem 2006 : Phosphatidylinositol 3-kinase/Akt auto-regulates PDGF-BB stimulated interleukin-6 synthesis in osteoblasts ... In the present study, we investigated whether the phosphatidylinositol 3-kinase (PI3K)/Akt is involved in the PDGF-BB induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... Taken together, these results strongly suggest that PI3K/Akt negatively regulates the PDGF-BB stimulated IL-6 synthesis in osteoblasts
Takai et al., Metabolism 2007 : In the present study, we investigated the mechanism of IL-6 synthesis induced by PDGF-BB in osteoblast-like MC3T3-E1 cells ... PD98059 ( an inhibitor of MAP kinase/extracellular signal regulated kinase kinase [ MEK ] ), SB203580 ( an inhibitor of p38 MAP kinase ), or SP600125 ( an inhibitor of SAPK/JNK ) suppressed the IL-6 synthesis induced by PDGF-BB ... Rapamycin, an inhibitor of p70 S6 kinase, significantly enhanced the PDGF-BB stimulated IL-6 synthesis ... These results strongly suggest that PDGF-BB stimulates IL-6 synthesis through activation of 3 MAP kinases in osteoblasts and that p70 S6 kinase negatively regulates the IL-6 synthesis
Takai et al., Mediators Inflamm 2008 : EGCG significantly reduced the IL-6 synthesis and IL-6 mRNA expression stimulated by PDGF-BB, EGCG reduced the PDGF-BB stimulated IL-6 synthesis also in primary cultured osteoblasts ... These results strongly suggest that EGCG inhibits the PDGF-BB stimulated synthesis of IL-6 via suppression of SAPK/JNK pathway in osteoblasts
Seidel et al., Am J Physiol Lung Cell Mol Physiol 2009 (Chronic Disease...) : TNFalpha induced eotaxin, RANTES, and IL-6 as well as PDGF-BB induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups
van Steensel et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy) : IL-6 , IL-8, CCL2, CCL5, and CCL7 production by orbital fibroblasts was increased by PDGF-BB stimulation, whereas IL-16, IL-1beta, and TNF-alpha production was not affected
Seidel et al., Schweiz Med Wochenschr 2010 : We determined the effect of DMF on platelet derived growth factor (PDGF)-BB induced proliferation, as well as on PDGF-BB and tumor necrosis factor (TNF)-a induced interleukin (IL)-6 secretion and on activation of activated protein (AP)-1 and nuclear factor kappaB ( NF-?B ) ... PDGF-BB and TNF-a induced IL-6 secretion by lung fibroblasts and this was inhibited by DMF in a dose dependent manner ... However, PDGF-BB induced IL-6 secretion did not correlate with NF-?B activity, while TNF-a did
Kato et al., Life Sci 2012 : AMP activated protein kinase regulates PDGF-BB stimulated interleukin-6 synthesis in osteoblasts : involvement of mitogen activated protein kinases ... In the present study, we investigated the involvement of AMP activated protein kinase (AMPK), a regulator of energy metabolism, in the PDGF-BB stimulated IL-6 synthesis in MC3T3-E1 cells ... Compound C, an inhibitor of AMPK, which reduced PDGF-BB induced acetyl-CoA carboxylase phosphorylation, dose-dependently suppressed the PDGF-BB stimulated IL-6 release ... In addition, the PDGF-BB stimulated IL-6 release in human osteoblasts was also inhibited by compound C ... The mRNA expression of IL-6 induced by PDGF-BB was markedly reduced by compound C ... These results strongly suggest that AMPK positively regulates PDGF-BB stimulated IL-6 synthesis via the MAP kinases in osteoblasts
Franchimont et al., Endocrinology 1995 : Phorbol 12-myristate 13-acetate ( PMA ) induced IL-6 transcripts, and the effect of PDGF BB was inhibited in the presence of the protein kinase C ( PKC ) inhibitor, sangivamycin, or after down-regulation of PKC by PMA preincubation ... Although forskolin increased IL-6 mRNA levels, PDGF BB did not induce cAMP production in Ob cells ... The calcium ionophore, ionomycin, enhanced IL-6 transcripts in Ob cells and the intracellular calcium chelator, 1,2-bis- ( o-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetra- ( acetoxymethyl ) -ester, inhibited the induction of IL-6 transcripts by PDGF BB , PMA, and PTH ... In conclusion, PDGF BB stimulates IL-6 expression in Ob cells, a response that is PKC and calcium dependent
Zhang et al., J Dermatol 1995 (Carcinoma, Squamous Cell) : Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma, interleukin-1 alpha, and tumor necrosis factor-alpha failed to exert any influence at all
Takemura et al., J Rheumatol 1998 (Scleroderma, Systemic) : Platelet derived growth factor (PDGF)-AA and PDGF-BB , a major growth factor in serum, induced significant IL-6 production by SSc fibroblasts