Hodge et al., Cancer Genomics Proteomics 2007
:
IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 ( DNMT1 ) via phosphorylation of the nuclear localization sequence by the AKT kinase
Braconi et al., Hepatology 2010
(Bile Duct Neoplasms...) :
MicroRNA dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes ... IL-6 can increase expression of DNA methyltransferase-1 (DNMT-1) and epigenetically regulate the expression of several genes, including microRNAs ( miRNAs ) ... Conclusion : These data indicate that IL-6 can regulate the activity of DNMT-1 and expression of methylation dependent tumor suppressor genes by modulation of miR-148a and miR-152, and provide a link between this inflammation associated cytokine and oncogenesis in cholangiocarcinoma
Li et al., Carcinogenesis 2012
(Cell Transformation, Neoplastic...) :
IL-6 induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis related colorectal cancer