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CD44 — IL6

Text-mined interactions from Literome

Fujii et al., Lab Invest 1999 (Arthritis, Rheumatoid) : Briefly, we found that ( a ) rheumatoid synovial cells highly expressed CD44 ; ( b ) crosslinking of CD44 augmented IL-6 production and its mRNA transcription ; ( c ) hyaluronan, especially when fragmented, also increased IL-6 production ; and ( d ) CD44 activated the transcription factor activator protein-1 and CAMP-responsive element binding protein
Van Driel et al., Leukemia 2002 (Multiple Myeloma) : The role of CD44v9 in adhesion induced IL-6 secretion and its preferential expression on IL-6 dependent plasma cell lines may explain the previously observed correlation between CD44v9 expression and adverse prognosis in multiple myeloma
Vincent et al., Leukemia 2004 (Multiple Myeloma) : IL-6 regulates CD44 cell surface expression on human myeloma cells ... In this report, we demonstrate that interleukin-6 (IL-6) , the main survival and growth factor for myeloma cells, strongly increases CD44 gene expression
Ishimoto et al., Cytokine 2012 : Knockdown of CD74, but not CD44 , inhibited rDDT induced IL-6 mRNA expression in SGBS cells
Han et al., Oncogene 1996 (Disease Progression...) : In vitro MELP cells express an IL2-R alpha ( + ) beta ( + ) gamma ( - ) phenotype and IL2 treatment induces the acquisition of new functional characteristics represented ( i ) by the increased surface expression of two markers of metastatic evolution ( ICAM-1 and CD44 ) ; ( ii ) by the stable induction of the IL2-R gamma with the appearance of functional IL2-R beta complex, which are also recognized by GM-CSF ; ( iii ) by the inhibition of transcription of a regulatory cytokine such as IL6 ; ( iv ) by a differential effect of IL6 on CD44 surface expression in MELP cells treated or not with IL2 ( MILG cells ) ; ( v ) by the acquisition of faster growth rates and appearance of piling up and multilayer cellular organization ; ( vi ) by the development of rapidly growing tumors in nude mice
Stauder et al., Blood 1996 (Disease Progression...) : In multiple myeloma ( MM ), CD44 mediates binding of tumor cells to stroma and regulates interleukin-6 production
García de Galdeano et al., Eur Cytokine Netw 1998 (Melanoma, Experimental) : Neither cell proliferation nor in vitro colony formation were affected by IL-6 ; however, the expression of CD44 and VLA-4 increased