Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Blank et al., J Immunol 2001 : Costimulation with OKT-3 and IL-2 optimally induced secretion of IFN-gamma , TNF-alpha, and IL-5, which was not decreased by CD45 signals
MacKenzie et al., Transplant Proc 2003 : Depletion of CD45 ( + ) cells resulted in the low levels of IFNgamma production at early time points ( day 4 ), which increased to near normal levels by day 7
Huang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004 (Myelodysplastic Syndromes) : The results showed that TNF-alpha, IFN-gamma levels in BM of MDS both increased , the former produced by cells CD4+CD45RO+ , CD8+CD45RO+, the latter by cells CD4+CD45RO+, CD8+CD45RO+, CD8+CD45RA+, in which the cells CD8+CD45RO+ were dominant
Komai-Koma et al., Eur J Immunol 2009 : Moreover, CD8 ( + ) CD45RO ( + ) memory T cells constitutively expressed TLR4 and markedly enhanced IFN-gamma production when stimulated with LPS
Jang et al., J Leukoc Biol 2009 : Furthermore, production of IL-23 in CBDC costimulated with LPS and IL-12 caused CD4 ( + ) CD45RO ( + ) memory cells to increase IFN-gamma production
Brod et al., J Exp Med 1989 : CD45RA expression could be further regulated by ionomycin or the cytokines IL-1 and IL-6, but not IL-2, IL-4, or IFN-gamma
Xu et al., J Immunol 1995 : Cross linking of CD45 on NK cells stimulates p56lck mediated tyrosine phosphorylation and IFN-gamma production
Shen et al., J Immunol 1995 : We report here that cross linking of CD45 specifically stimulates IFN-gamma production in human NK cells