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Viau et al., J Clin Invest 2010
(Disease Progression...) :
EGFR inhibition prevented Lcn2 upregulation and lesion development in mice expressing a dominant negative EGFR isoform, and hypoxia-inducible factor 1a (Hif-1a) was crucially required for EGFR induced Lcn2 overexpression
Yang et al., FASEB J 2013
(Breast Neoplasms...) :
We further demonstrate that Lcn2 induced VEGF is mediated through hypoxia-inducible factor 1a (HIF-1a) and that Lcn2 regulates HIF-1a through extracellular signal regulated kinase ( Erk ) ... The regulation of HIF-1a and VEGF by Lcn2 was also demonstrated in the aggressive MDA-MB-231 cell line
Sickinger et al., Transpl Int 2013
:
HIF-1ß expression led to a 2.4-fold induction of the Lcn2 promoter