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EGFR — PI3

Text-mined interactions from Literome

Wu et al., Oncogene 2000 (Brain Neoplasms...) : Inhibition of EGFR mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins ( SIRPs )
Pianetti et al., Oncogene 2001 (Breast Neoplasms...) : Overexpression of Her-2/neu and EGFR-4 in Ba/F3 cells led to constitutive PI3- and Akt kinase activities, and induction of classical NF-kappaB ( p50/p65 )
Auge et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : Coimmunoprecipitation experiments and the use of inhibitors and dominant negative mutant showed that oxLDL induced PI-3K activation is dependent on EGFR
Hassan et al., Regul Pept 2004 (Prostatic Neoplasms) : The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor ( U73122 ), PKC-inhibitors ( bisindolylmaleimide, staurosporine, rottlerin ), MEK inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin, LY 294002 )
Cappuzzo et al., J Natl Cancer Inst 2004 (Carcinoma, Non-Small-Cell Lung...) : Phosphatidylinositol 3'-kinase (PI3K)/Akt and Ras/Raf/mitogen activated protein kinase ( MAPK ), the two main EGFR signaling pathways, mediate EGFR effects on proliferation and survival
Le Page et al., Prostate 2005 (Prostatic Neoplasms) : Independent role of phosphoinositol-3-kinase (PI3K) and casein kinase II ( CK-2 ) in EGFR and Her-2 mediated constitutive NF-kappaB activation in prostate cancer cells
Ihle et al., Mol Cancer Ther 2005 (Carcinoma, Non-Small-Cell Lung...) : Recent work shows that phosphatidylinositol-3-kinase (PI3-K) is coupled to the EGFR only in NSCLC cell lines expressing ErbB-3 and that EGFR inhibitors do not inhibit PI3-K signaling in these cells
Nie et al., Mech Dev 2007 : In this study, we show that phosphatidylinositol-3 kinase (PI3K) and Erk mitogen activated protein kinase ( MAPK ) mediate ErbB signaling to regulate gastrulation
Rodland et al., J Biol Chem 2008 (MAP Kinase Signaling System) : This enhancement of EGFR signaling was independent of both receptor phosphorylation and PI-3-kinase activity, suggestive of a novel mechanism
Yin et al., Invest Ophthalmol Vis Sci 2010 : Heparin binding EGF-like growth factor ( HB-EGF ) shedding was assessed by measuring the release of alkaline phosphatase ( AP ) in a stable HCEC line expressing HB-EGF-AP. Activation of EGFR , phosphoinositide 3-kinase (PI3K) , and extracellular signal regulated kinases 1/2 ( ERK1/2 ) was determined by Western blot analysis
Su et al., Clin Exp Pharmacol Physiol 2010 : The results indicated that CTX III suppresses phosphorylation of EGFR and activation of phosphatidylinositol 3-kinase (PI3-K)/Akt and Janus tyrosine kinase (JAK) 2/signal transducer and activator of transcription ( STAT ) 3, all of which are downstream molecules in the EGFR signalling pathway
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : In conclusion, PAR(2) activation drives COX-2 expression in Caco-2 cells via metalloproteinase dependent EGFR transactivation and activation of Src, Rho, and PI3 kinase signaling
Tabara et al., PloS one 2012 (Lung Neoplasms) : However, constitutive activation of EGFR downstream signaling, PI3K/Akt , was observed even after loss of the mutated EGFR gene in all resistant cell lines even in the presence of the drug
Zhang et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2011 : These findings suggest that exogenous 14,15-EET has potent inhibitory effect on proliferation, and could induce apoptosis in Tca-8113 cell, and these changes are related to the expression of PPAR?, the activation of EGFR , ERK, and PI3 kinase/AKT proteins
Kim et al., J Neurochem 2013 (MAP Kinase Signaling System) : Stimulation of the ErbB receptors by NRG1ß activated the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK )
Li et al., Cancer Biother Radiopharm 2013 (Adenocarcinoma...) : Recent evidence indicates that both the phosphatidylinositol 3-kinase (PI3K)/AKT and the MEK/ERK pathways are strictly regulated by epidermal growth factor receptor in non-small cell lung cancer ( NSCLC ) that responds to Gefitinib
Weiss et al., Journal of gastrointestinal oncology 2013 : Phosphatidylinositol-3-kinase (PI3K) activation involves the epidermal growth factor receptor (EGFR) and plays an important role in cell survival signaling in pancreaticobiliary cancer