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EGFR — ESR1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ESR1 — EGFR (physical association, affinity chromatography technology) Hitosugi et al., J Biol Chem 2007*
• IRef Hprd Interaction: ESR1 — EGFR (in vitro) Márquez et al., Endocrine 2001*
• IRef Intact Interaction: Complex of SRC-EGFR-ESR1 (association, anti bait coimmunoprecipitation) Hitosugi et al., J Biol Chem 2007*
• IRef Intact Interaction: ESR1 — EGFR (physical association, anti tag coimmunoprecipitation) Zhang et al., Oncogene 2011*
• IRef Intact Interaction: ESR1 — EGFR (physical association, anti bait coimmunoprecipitation) Zhang et al., Oncogene 2011*
• IRef Intact Interaction: ESR1 — EGFR (physical association, anti bait coimmunoprecipitation) Hitosugi et al., J Biol Chem 2007*
• IRef Ophid Interaction: ESR1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ESR1 — EGFR (aggregation, confirmational text mining) Márquez et al., Endocrine 2001*

Text-mined interactions from Literome

Stoica et al., Oncogene 2003 : Experiments employing selective ErbB inhibitors demonstrate that the effect of HRG-beta1 on ER-alpha expression and activity is also mediated by ErbB2 and not by EGFR , demonstrating that ErbB2 is the primary mediator of the effects of HRG-beta1 on ER-alpha regulation
Stoica et al., Oncogene 2003 (Breast Neoplasms) : Experiments employing selective ErbB inhibitors demonstrate that the effect of estradiol on ER-alpha expression and activity is mediated by ErbB2 and not by EGFR
Johnston et al., Clin Cancer Res 2006 (Breast Neoplasms) : The increasing recognition of the roles of epidermal growth factor receptor (EGFR) and human EGFR2 in cross-talk activation of estrogen receptor signaling has led to studies aimed at identifying whether small-molecule tyrosine kinase inhibitors targeted against these receptors give additive or synergistic effects when combined with endocrine agents
Albanito et al., Cancer Res 2007 (Breast Neoplasms...) : Whether estrogen receptor alpha (ERalpha) also contributes to GPR30/EGFR signaling is less understood
Burga et al., Breast Cancer Res 2011 (Cell Transformation, Neoplastic...) : Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor negative cancers in BRCA1-mutant mice
Fitzpatrick et al., Cancer Res 1984 (Breast Neoplasms) : Epidermal growth factor receptors ( EGF-R ) were measured in a series of breast tumors to determine what percentage of breast tumors express EGF-R and whether EGF-R was independent of expression of estrogen receptor and progestin receptor
Sheikh et al., J Cell Biochem 1994 (Breast Neoplasms...) : Recent studies suggest that the epidermal growth factor-receptor does not regulate the estrogen receptor gene expression ... Whether the estrogen receptor regulates the epidermal growth factor-receptor gene expression is not known
deFazio et al., Cell Growth Differ 1997 (Breast Neoplasms) : Antisense estrogen receptor RNA expression increases epidermal growth factor receptor gene expression in breast cancer cells