Gene interactions and pathways from curated databases and text-mining

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EPHB2 — GNRH2

Text-mined interactions from Literome

Kim et al., J Clin Endocrinol Metab 2005 (Adenocarcinoma...) : In the present study, we further investigated the involvement of GnRH-II in the inhibition of cell proliferation and activation of ERK1/2 and c-Jun N-terminal protein kinase/stress activated protein kinase ( JNK/SAPK ) in ovarian cancer cells, OVCAR-3 ... Western blot analysis demonstrated that ERK1/2 was activated by GnRH-II ( 100 nm ) ... The activation of ERK1/2 by GnRH-II subsequently phosphorylated Elk-1 as a downstream pathway, which was blocked by PD98059
Klausen et al., Am J Physiol Regul Integr Comp Physiol 2005 (MAP Kinase Signaling System) : PKC and ERK are differentially involved in gonadotropin releasing hormone induced growth hormone gene expression in the goldfish pituitary
Caunt et al., J Biol Chem 2006 : Arrestin mediated ERK activation by gonadotropin releasing hormone receptors : receptor-specific activation mechanisms and compartmentalization
Zhao et al., Zhonghua Fu Chan Ke Za Zhi 2009 (Endometrial Neoplasms) : Triptorelin and GnRH-II inhibited the Akt and ERK1/2 activity in the endometrial carcinoma cells