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IL1A — PIK3R1

Text-mined interactions from Literome

Schmid et al., Cancer Cell 2011 (Disease Progression...) : Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k? , a single convergent point promoting tumor inflammation and progression
Wu et al., Particle and fibre toxicology 2012 (MAP Kinase Signaling System) : Pharmacological inhibition of ERK kinase and PI3K activity blocked DEP induced IL-8 and IL-1ß expression
Busch et al., J Biol Chem 2012 : Resveratrol suppressed IL-1ß induced activation of NF-?B and PI3K in a dose- and time dependent manner ... IL-1ß induced NF-?B and PI3K activation was inhibited by resveratrol or the inhibitors of PI3K ( wortmannin ), c-Src ( PP1 ), and Akt ( SH-5 ) through inhibition of I?B kinase, I?Ba phosphorylation, and inhibition of nuclear translocation of NF-?B, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-?B activation ... The modulatory effects of resveratrol on IL-1ß induced activation of NF-?B and PI3K were found to be mediated at least in part by the association between Sirt-1 and scleraxis and deacetylation of NF-?B and PI3K