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IL3 — STAT1
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and
STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999
:
Interestingly,
interleukin (IL)-7 selectively
activated STAT1 and induced MHC class I in mature T but not B cells
Ochiai et al., Int Arch Allergy Immunol 2001
:
The
role of
STAT1 in activation of
IL-3- and IL-5 induced eosinophils by interferon gamma
Bovolenta et al., Blood 2002
(Leukemia, Erythroblastic, Acute) :
Activation of signal transducer and activator of transcription ( STAT ) 5 protein occurred in TF-1 cells incubated either with IL-3 or with HTLV-2/CMo ; in addition the virus, but not
IL-3 ,
activated STAT1
Gündogdu et al., Molecular cancer 2010
:
High levels of RhoH allow the
IL3 dependent activation of
STAT1 causing decreased proliferation through upregulation of p21Cip1 and p27Kip1
Nagata et al., Biochem Biophys Res Commun 1996
:
Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2,
STAT1 , and STAT3 ... Furthermore, we found that
IL3 induces activation of not only STAT5 but also
STAT1 and STAT3
Kirito et al., J Biol Chem 1997
:
This indicates that
IL-3 , GM-CSF, and EPO commonly
activated Stat1alpha , Stat3, and Stat5 proteins in UT-7 ... Thus, although
Stat1alpha , Stat3, and Stat5 proteins are
activated by GM-CSF,
IL-3 , and EPO, our data suggest that each STAT protein has a distinctive role in the actions of cytokines
Quentmeier et al., Leukemia 1998
(Polyploidy) :
IL-3 and IFN gamma
induced phosphorylation of STAT 5 or
STAT 1 , respectively, without affecting the other STATs