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RAC2 — RHOA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Pertz et al., Nature 2006
:
Current models postulate that
Rac promotes membrane protrusion at the leading edge and that
RhoA regulates contractility in the cell body
Matthews et al., Development 2008
:
In addition, we show that
RhoA inhibits
Rac in NC cells
Wu et al., Nature 2009
:
Rac was shown to
inhibit RhoA in mouse embryonic fibroblasts, with inhibition modulated at protrusions and ruffles
Alcaide et al., Am J Physiol Cell Physiol 2012
:
Interestingly, overexpression of either p120-4A or p120-1A dramatically blocked TEM, and overexpression of p120-1A in HUVEC did not affect
RhoA basal activity or
activation of RhoA and
Rac induced by thrombin or ICAM-1 crosslinking
Sells et al., Curr Biol 1997
:
In mammalian cells, Cdc42 regulates the formation of filopodia, whereas
Rac regulates lamellipodia formation and membrane ruffling, and
RhoA regulates the formation of stress fibers