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IL15 — IL15RA

Pathways - manually collected, often from reviews:

• KEGG Intestinal immune network for IgA production: IL15 → IL15RA (protein-protein, binding/association)
• KEGG Cytokine-cytokine receptor interaction: IL15 → Complex of IL15RA-IL2RB-IL2RG (protein-protein, activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: IL15 — IL15RA (physical association, biochemical) Lehours et al., Eur Cytokine Netw 2000*
• IRef Hprd Interaction: IL15 — IL15RA (in vivo) Mortier et al., J Biol Chem 2006*, Giri et al., EMBO J 1995*
• IRef Hprd Interaction: IL15 — IL15RA (in vitro) Mortier et al., J Biol Chem 2006*, Giri et al., EMBO J 1995*
• IRef Innatedb Interaction: IL15 — IL15RA (unknown, -) Mortier et al., J Biol Chem 2006*
• IRef Intact Interaction: IL15 — IL15RA (physical association, surface plasmon resonance) Mortier et al., J Biol Chem 2006*
• IRef Ophid Interaction: IL15 — IL15RA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: IL15 — IL15RA (aggregation, confirmational text mining) Giri et al., EMBO J 1995*

Text-mined interactions from Literome

de Jong et al., Cytokine 1998 : This indicates that the role of IL-15Ralpha in the high affinity IL-15R complex is distinct from that of IL-2Ralpha in the high affinity IL-2R complex
Handisurya et al., Prostate 2001 (Prostatic Hyperplasia...) : Overexpression of IL-15 and IL-15Ralpha-chain in BPH and massive proliferation of BPH-T-lymphocytes induced by IL-15 suggest a role for IL-15 in prostatic inflammation
Nishiwaki et al., J Gastroenterol 2005 (Colitis, Ulcerative...) : The effects of recombinant ( r ) IL-15 on the expression of IL-15Ralpha on lamina propria B cells and the production of immunoglobulin G ( IgG ) were analyzed in vitro, using lamina propria mononuclear cells ( LPMCs ) isolated from control tissues
Dubois et al., J Immunol 2008 (Melanoma, Experimental) : When injected into mice, IL-15Ralpha-IgG1-Fc enhanced the capacity of IL-15 to expand the number of NK and CD8 ( + ) /CD44 ( high ) T cells ... When mice bearing the NK-sensitive syngeneic tumor B16 were treated, the presence of IL-15Ralpha-IgG1-Fc increased the antitumor activity of IL-15
Mortier et al., J Exp Med 2008 : IL-15Ralpha is required for IL-15 production by DCs, and IL-15 that emerges onto the cell surface of matured DCs does not bind to neighboring cells expressing IL-15Ralpha
Bergamaschi et al., J Immunol 2009 : Coexpression of both LSP IL-15 and SSP IL-15 in the presence of IL-15Ralpha results in lower levels of bioactive IL-15 , indicating that LSP and SSP IL-15 compete for the binding to IL-15Ralpha when expressed in the same cell