◀ Back to IL15
CD28 — IL15
Text-mined interactions from Literome
Agostini et al., Am J Physiol 1999
(Sarcoidosis) :
However, stimulation with
IL-15 induced the expression of Th1-type cytokines ( IFN-gamma ) and
CD28 on sarcoid T cells, suggesting a role for this macrophage derived cytokine in the activation of the sarcoid T-cell pool
Okkenhaug et al., Nat Immunol 2001
:
Nonetheless, this mutated form of
CD28 still prevents the induction of anergy and
promotes T cell proliferation,
interleukin 2 secretion and B cell help
Kim et al., Blood 2002
:
The 4-1BB was induced preferentially on the CB CD28 ( - ) CD8 ( + ) T cells when
CD28 down-regulation was
induced by
interleukin 15 (IL-15) and IL-12 stimulation
Lin et al., Am J Hematol 2005
:
IL-15 but not IL-2
down-regulated CD28 expression on both activated CB and APB CD8+ T cells, with a much greater effect seen with CB
Ortega et al., J Leukoc Biol 2009
(Psoriasis) :
These cells are refractory to Tregs but show a proliferative response to
anti-CD3/CD28 stimulation that is
enhanced by IL-12 and
IL-15
Abreu et al., Arthritis Res Ther 2010
(Arthritis, Experimental...) :
Ex vivo, Rac1 inhibitory peptide suppressed T-cell
receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and
interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Chen et al., Cytokine 2012
(Graft vs Host Disease) :
Regulation of
CD28 expression on umbilical cord blood and adult peripheral blood CD8+ T cells by
interleukin(IL)-15/IL-21
Brunner et al., Aging Cell 2012
:
Interleukin (IL)-15 could prevent etoposide mediated apoptosis of CD8 ( + ) CD28 ( - ) T cells, suggesting a
role for
IL-15 in the survival and the age dependent accumulation of CD8 ( + )
CD28 ( - ) T cells in humans
Yu et al., Asian Pac J Trop Med 2013
(Melanoma) :
Artificial antigen presenting cells plus
IL-15 and IL-21 efficiently
induce melanoma-specific cytotoxic CD8 ( + )
CD28 ( + ) T lymphocyte responses