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ELAVL1 — PTGS2
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Dixon et al., J Clin Invest 2001
(Colonic Neoplasms) :
Altered expression of the mRNA stability factor
HuR promotes
cyclooxygenase-2 expression in colon cancer cells ... In particular, we found that the RNA-stability factor HuR binds to the COX-2 ARE, and overexpression of
HuR , as detected in tumors,
results in elevated expression of
COX-2 , VEGF, and IL-8
Sengupta et al., J Biol Chem 2003
:
The RNA binding protein
HuR regulates the expression of
cyclooxygenase-2
Subbaramaiah et al., J Biol Chem 2003
:
Overexpression of antisense
HuR suppressed taxane mediated induction of
COX-2 3'-UTR activity
Erkinheimo et al., Cancer Res 2003
(Cystadenocarcinoma, Serous...) :
Our results show that cytoplasmic HuR expression associates with poor outcome in ovarian cancer, and one plausible explanation for this finding may be related to the ability of
HuR to
induce COX-2 expression
Erkinheimo et al., Gynecol Oncol 2005
(Adenocarcinoma, Mucinous...) :
HuR is an mRNA stability protein and it
regulates the expression of
COX-2
Mrena et al., Clin Cancer Res 2005
(Adenocarcinoma...) :
Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is
regulated by the messenger RNA stability factor
HuR ... Cytoplasmic expression of HuR associates with high COX-2 expression and with reduced survival, and tissue culture experiments show that
HuR can
regulate expression of
COX-2 in gastric cancer cells
Sureban et al., Gastroenterology 2007
:
The
effect of CUGBP2 and
HuR on
COX-2 ARE dependent translation was shown by a chimeric luciferase mRNA containing COX-2 3'UTR
Niesporek et al., Int J Oncol 2008
(Carcinoma...) :
HuR inhibition by Leptomycin B
reduced the inducibility of
COX-2 in PC-3 prostate cancer cells
Young et al., Gastroenterology 2009
(Adenocarcinoma...) :
HuR and TTP-inducible cells were created to investigate
HuR- and TTP mediated
regulation of
COX-2 ... HuR overexpression in cells up-regulated COX-2 expression, whereas overexpression of TTP inhibited it ; limited TTP expression antagonized
HuR mediated
COX-2 overexpression
Fernau et al., J Biol Chem 2010
:
Role of
HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of
COX-2 expression in the human keratinocyte cell line HaCaT
Kim et al., Mod Pathol 2011
(Adenocarcinoma...) :
Expression of
HuR , COX-2, and survivin in lung cancers ; cytoplasmic HuR
stabilizes cyclooxygenase-2 in squamous cell carcinomas