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ALOX15 — PTGS2

Text-mined interactions from Literome

Wu et al., Carcinogenesis 2003 (Stomach Neoplasms) : We found that : ( i ) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis ; ( ii ) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis ; ( iii ) SC-236 did not affect expression of COX-1, COX-2 , 5-LOX and 12-LOX ; and ( iv ) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis
Xu et al., Neoplasia (New York, N.Y.) 2003 (Esophageal Neoplasms) : The COX-2 inhibitor, NS398, induced 15-LOX-2 expression in esophageal cancer cells, which is associated with reduced cell viability