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IL8 — TP53
Text-mined interactions from Literome
Yuan et al., J Clin Oncol 2002
(Carcinoma, Non-Small-Cell Lung...) :
This result indicates that aberrant
p53 expression may
play a significant role in regulation of VEGF and
IL-8 expression and be involved in controlling angiogenesis and explains the adverse prognosis of cancers with high aberrant p53 expression
Hidaka et al., J Exp Clin Cancer Res 2005
(Neoplasms) :
These results show that
wt-p53 gene transfer
inhibits IL-8 production and NF-kappaB transcription activity in cancer cells and suggest that constitutive IL-8 production in cancer cells is associated with mutation of p53
Dreij et al., Carcinogenesis 2010
(Inflammation) :
We confirmed this hypothesis by showing that
p53 dependent signaling through c-jun N-terminal kinase ( JNK ) led to increased cJun-Ser63 phosphorylation and that inhibition of JNK mediated cJun activation using p53- or JNK-specific inhibitors significantly
reduced IL gene expression and subsequent production of
IL8