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CCND1 — ILK
Text-mined interactions from Literome
D'Amico et al., J Biol Chem 2000
(Breast Neoplasms) :
The
integrin linked kinase regulates the
cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element binding protein dependent pathways ... We show here that
ILK overexpression elevates cyclin D1 protein levels and directly
induces the
cyclin D1 gene in mammary epithelial cells ... Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced
ILK induction of
cyclin D1 expression ... We conclude that the cyclin D1 gene is regulated by the Wnt-1 and ILK signaling pathways and that
ILK induction of
cyclin D1 involves the CREB signaling pathway in mammary epithelial cells
Li et al., J Am Soc Nephrol 2009
(Disease Models, Animal...) :
Pharmacologic inhibition of
ILK with small-molecule inhibitor QLT-0267 abolished TGF-beta1 induced phosphorylation of Akt and glycogen synthase kinase-3beta,
suppressed cyclin D1 expression, and largely restored the expression of E-cadherin and zonula occludens 1
Radeva et al., J Biol Chem 1997
:
ILK overexpression
results in increased expression of
cyclin D1 , activation of Cdk4 and cyclin E-associated kinases, and hyperphosphorylation of the retinoblastoma protein