◀ Back to RAC1

RAC1 — TGFB1

Text-mined interactions from Literome

Han et al., J Clin Invest 2005 (Carcinoma in Situ...) : However, Delta ( beta ) RII did not alter TGF-beta1 mediated expression of RhoA/Rac and MAPK, which contributed to increased metastasis
Varon et al., Exp Cell Res 2006 : Thus, Rac1 and RhoA are regulated by TGFbeta1 in the process of endothelial tube formation in collagen I gels
Hubchak et al., American journal of physiology. Renal physiology 2009 (Fibrosis) : TGF-beta1 activated both RhoA and Rac1 within 5 min of treatment, and this activation was dependent on the kinase activity of the type I TGF-beta receptor ... Furthermore, the PI3K antagonist, LY294002, reduced TGF-beta1 stimulated COL1A2 promoter activity and Rac1 activation ... Thus, while both Rac1 and RhoA are rapidly activated in response to TGF-beta1 in human mesangial cells, only Rac1 activation enhances events that contribute to mesangial cell collagen expression, through a positive feedback loop involving PI3K
Vivien et al., J Cell Physiol 1993 : We previously showed that TGF-beta 1 increased DNA replication rate of RAC , with a recruitment of cells in G2/M followed by a subsequent mitosis wave