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APC — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): RAC1/GDP complex (RAC1) → APC/ASEF complex (APC-ARHGEF4) (modification, collaborate)
  Kawasaki et al., J Biol Chem 2009*
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Corum Interaction: Complex of APC-IQGAP1-RAC1 (association, anti bait coimmunoprecipitation) Watanabe et al., Dev Cell 2004*

Text-mined interactions from Literome

Finigan et al., J Biol Chem 2005 (Sepsis) : We next determined that APC directly increases Rac1 activity, with inhibition of Rac1 activity significantly attenuating APC mediated barrier protection to thrombin challenge
Russo et al., Proc Natl Acad Sci U S A 2009 : To delineate the mechanism responsible for protease-selective signaling by PAR(1), we examined the effect of APC and thrombin on the activation of RhoA and Rac1 , small GTPases that differentially regulate endothelial barrier permeability ... Thrombin caused robust RhoA signaling but not Rac1 activation, whereas APC stimulated a marked increase in Rac1 activation but not RhoA signaling, consistent with the opposing functions of these proteases on endothelial barrier integrity
Soh et al., Proc Natl Acad Sci U S A 2011 : Remarkably, we found that depletion of ß-arrestin expression by RNA interference resulted in the loss of APC induced Rac1 activation but not of thrombin stimulated RhoA signaling