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CHUK — TNFRSF8
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Horie et al., Drug News Perspect 2003
(Hodgkin Disease) :
Epstein-Barr virus latent membrane protein (LMP)-1, defective IkappaBalpha,
IkappaB kinase activation and ligand independent signaling by overexpressed
CD30 have been clarified in the past several years
Nonaka et al., Oncogene 2005
(Cell Transformation, Neoplastic...) :
We also demonstrate that overexpression of
CD30 in rat fibroblasts at levels comparable to those in H-RS cells
results in constitutive
IkappaB kinase activation, proteasome dependent p100 processing, and NF-kappaB dependent cell transformation