Jin et al., Proc Natl Acad Sci U S A 2002
:
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS activated TNF-alpha responses
Sebastiani et al., Neurobiol Aging 2006
:
Inhibition of Pde4B reduces by up to 70 % the release of TNF-alpha from sAbeta stimulated microglial cells, implicating cAMP as an important mediator of Abeta induced microglial activation
Gobejishvili et al., Am J Physiol Gastrointest Liver Physiol 2008
(Hepatitis, Alcoholic) :
These findings strongly support the pathogenic role of PDE4B in the ethanol mediated priming of monocytes/macrophages and increased LPS-inducible TNF production and the subsequent development of alcoholic liver disease (ALD)
Zhang et al., Endocrinology 2009
(Panniculitis) :
PDE4B deficiency suppressed TNF-alpha mRNA levels and macrophage infiltration in white adipose tissue in mice on HFD, but insulin sensitivity was unaltered
Ghosh et al., Glia 2012
(Central Nervous System Diseases...) :
Immunoblotting for PDE4 showed that both cytokines increased PDE4A1, but only TNF-a increased PDE4B2