Coulonval et al., Exp Cell Res 2003
:
In the presence of TSH, transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4, but it strongly inhibited the pRb-kinase activity associated with both cyclin D3 and p27, not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to p27, but also by inhibiting CDK4 phosphorylation within residual p27 bound cyclin D3-CDK4 complexes
Quesnel et al., Blood 1998
(Myelodysplastic Syndromes) :
p15(INK4b) gene is an inhibitor of cyclin dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor ( TGF ) beta