◀ Back to IRF6

IRF6 — NFKBIZ

Text-mined interactions from Literome

Yamauchi et al., Int Immunol 2007 (Genetic Predisposition to Disease...) : Thus, we hypothesized that Ifi202 is involved in elevated IL-12 production from BWF1 BMDCs. Overexpression of Ifi202 enhanced the LPS induced IkappaB-zeta , IL-12p40 and NF-kappaB promoter activities, while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line, RAW 264.7 ... Furthermore, overexpression of Ifi202 enhanced LPS induced IL-12p40 and IkappaB-zeta mRNA induction while Ifi202 AS RNA suppressed these in RAW 264.7 cells
Dagvadorj et al., Innate Immun 2009 : The expression of IkappaB-zeta , which promotes IL-6 production, was induced in response to LPS and it was definitely suppressed in the presence of IL-10 ... A pharmacological inhibitor of NF-kappaB prevented LPS induced IkappaB-zeta expression, suggesting that IL-10 might inhibit LPS induced IkappaB-zeta expression via the inactivation of NF-kappaB ... Therefore, it was suggested that Bcl-3 induced by IL-10 might reduce LPS induced IkappaB-zeta activity via inactivation of NF-kappaB and that reduced IkappaB-zeta activity failed to promote LPS induced IL-6 production