Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Liao et al., J Biol Chem 2004 (MAP Kinase Signaling System) : The cytokine enhanced gamma-secretase activity can be suppressed by a potent inhibitor of c-Jun N-terminal kinase (JNK)
Shen et al., J Biol Chem 2008 (Alzheimer Disease) : Here we show that the pro-oxidant H ( 2 ) O ( 2 ) promotes Abeta production through c-Jun N-terminal kinase (JNK) dependent activation of gamma-secretase
Kuo et al., Mol Biol Cell 2008 : Tumor necrosis factor-alpha elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase dependent phosphorylation of presenilin and nicastrin