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Eum et al., Exp Cell Res 2004 (Breast Neoplasms...) : In addition, the PI3K dependent pathway was involved in PCB 104 induced activation of AP-1 , a transcription factor implicated in the regulation of VEGF gene expression
Shimokawa et al., Neurotoxicology 2006 : Here we investigated the expression of c-Jun in response to PCB ... The level of c-Jun expression was increased by OH-PCB at relatively low-dose ; concentration of OH-PCB at 10 ( -8 ) M and 10 ( -7 ) M produced a 2.4- and 3.5-fold increase of c-Jun expression in respectively, compared with the values without OH-PCB treatment ... To determine whether the activation of Ca2+ channel is involved in the OH-PCB induced c-Jun expression, we examined it using a L-type voltage gated Ca2+ channel blocker nimodipine ... Nimodipine partially inhibited OH-PCB induced c-Jun expression by 50 % ... Moreover, Na+ channel antagonist tetrodotoxin inhibited OH-PCB induced c-Jun expression completely
Eum et al., Toxicological sciences : an official journal of the Society of Toxicology 2006 : Site directed mutagenesis of the IL-8 promoter- and DNA binding assays revealed that activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB) sites are required for PCB 104 induced IL-8 transcription