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MALT1 — NFKB1
Pathways - manually collected, often from reviews:
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KEGG Tuberculosis:
Complex of BCL10-CARD9-MALT1
→
NFKB1/RELA
(protein-protein, activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Vega et al., Adv Anat Pathol 2001
(Lymphoma, B-Cell, Marginal Zone...) :
Recent work suggests that
API2-MALT1 and BCL-10-MALT1 may
activate NF-kB and a common downstream signaling pathway
Che et al., J Biol Chem 2004
(Lymphoma, B-Cell, Marginal Zone) :
MALT1/paracaspase is a signaling component downstream of CARMA1 and
mediates T cell receptor induced
NF-kappaB activation ... Expression of a
MALT1 deletion mutant containing only the N-terminal death domain and the two Ig-like domains completely
blocked CD3/CD28 costimulation induced, but not tumor necrosis factor-alpha induced,
NF-kappaB activation
Lynch et al., Mol Interv 2004
:
Overexpression of
MALT1 , as observed in a subset of lymphoma patients,
leads to the potent activation of
NF-kappaB , suggesting that MALT1 might stimulate ( directly or indirectly ) the kinase complex [ IKK, inhibitor of NF-kappaB (IkappaB) kinase ] responsible for activating cytoplasmic NF-kappaB for translocation into the nucleus
Hosokawa et al., Int J Hematol 2004
(Lymphoma, B-Cell, Marginal Zone) :
Recent genetic and biochemical studies have indicated that BCL10 and
MALT1 form a physical and functional complex and are both
essential for
nuclear factor kappaB (NF-kappaB) activation by antigen receptor stimulation in lymphocytes ... BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation can be assumed to be able to contribute to antiapoptosis, probably through NF-kappaB mediated up-regulation of several apoptotic inhibitor genes
Ho et al., Blood 2005
(Lymphoma, B-Cell...) :
API2-MALT1 and exogenous MALT1
increased constitutive
NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation
Ye et al., J Pathol 2005
(Lymphoma, B-Cell, Marginal Zone...) :
The oncogenic activity of the three chromosomal translocations is linked by the physiological
role of BCL10 and
MALT1 in antigen receptor mediated
NFkappaB activation
Hosokawa et al., Apoptosis 2005
(Lymphoma, B-Cell, Marginal Zone...) :
This stability of
API2-MALT1 may thus
result in inappropriate
nuclear factor (NF)-kappaB activation, thereby contributing to the pathogenesis of MALT lymphoma ... Recent biochemical and genetic studies have clearly shown that BCL10 and
MALT1 form a physical and functional complex and are both
required for
NF-kappaB activation by antigen receptor stimulation in T and B lymphocytes ... Furthermore, BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation may contribute to anti-apoptotic action probably through NF-kappaB mediated upregulation of apoptotic inhibitor genes
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
While both BCL10 and
MALT1 are critically
involved in antigen receptor mediated
NF-kappaB activation, the role of cIAP2 is not clear ... Furthermore, BCL10 and
cIAP2-MALT1 synergistically
activate NF-kappaB
Zhou et al., Br J Haematol 2006
(Lymphoma, B-Cell, Marginal Zone...) :
t ( 11 ; 18 ) ( q21 ; q21 ) occurs specifically in mucosa associated lymphoid tissue ( MALT ) lymphoma and the translocation generates a functional
API2-MALT1 fusion product that
activates nuclear factor (NF)kappaB
Nakagawa et al., Leukemia 2006
(Lymphoma, B-Cell, Marginal Zone) :
Several lines of evidence indicated that both BCL10 and
MALT1 are
required for
nuclear factor kappa B (NF-kappaB) activation by antigen receptor stimulation in lymphocytes, and API2-MALT1 can bypass this BCL10/MALT1 signaling pathway ... We recently demonstrated that
API2-MALT1 can
induce transactivation of the API2 gene through
NF-kappaB activation, thus highlighting a positive feedback-loop mechanism of self-activation by upregulating its own expression in t ( 11 ; 18 ) MALT lymphomas
Rivera et al., Trends Immunol 2006
:
The
CARMA1-Bcl10-Malt1 adaptor complex
regulates NFkappaB activation by antigen receptors in lymphocytes
Hu et al., Cell cycle (Georgetown, Tex.) 2006
:
Furthermore,
cIAP2-MALT1 and Bcl10 synergistically
activate NF-kappaB
Gross et al., Nature 2006
:
Card9 couples to Bcl10 and regulates
Bcl10-Malt1 mediated
NF-kappaB activation induced by zymosan
Klemm et al., Proc Natl Acad Sci U S A 2007
:
Bcl10 and
Malt1 control lysophosphatidic acid induced
NF-kappaB activation and cytokine production ... By using murine embryonic fibroblasts from Bcl10- or Malt1-deficient mice as a genetic model, we report that Bcl10 and
Malt1 are critically
required for the degradation of IkappaB-alpha and the subsequent
NF-kappaB induction in response to LPA stimulation
McAllister-Lucas et al., Proc Natl Acad Sci U S A 2007
(Inflammation) :
CARMA3/Bcl10/MALT1 dependent
NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
Jost et al., J Immunol 2007
:
Bcl10/Malt1 signaling is
essential for TCR induced
NF-kappaB activation in thymocytes but dispensable for positive or negative selection
Noels et al., J Biol Chem 2007
(Lymphoma, B-Cell, Marginal Zone...) :
Finally, binding of TRAF2 to BIR1 contributed to
NF-kappaB activation by
API2.MALT1 , although additional mechanisms involving BIR1 mediated raft association are also important
Lucas et al., Oncogene 2007
:
A dual role for the API2 moiety in
API2-MALT1 dependent
NF-kappaB activation : heterotypic oligomerization and TRAF2 recruitment ... Thus, API2 moiety mediated heterotypic oligomerization and TRAF2 binding both contribute to maximal
API2-MALT1 dependent
NF-kappaB stimulation
Wegener et al., Science's STKE : signal transduction knowledge environment 2007
:
CARD11 ( CARMA1 ), Bcl10, and
Malt1 are
required for nuclear factor
NF-kappaB activation in response to antigen recognition
Hara et al., Nat Immunol 2007
(Listeriosis) :
The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells ... The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Rebeaud et al., Nat Immunol 2008
:
In contrast,
MALT1 activity but not Bcl-10 cleavage was
essential for optimal activation of transcription factor
NF-kappaB and production of interleukin 2
Kingeter et al., J Immunol 2008
:
Loss of protein kinase C theta, Bcl10, or
Malt1 selectively
impairs proliferation and
NF-kappa B activation in the CD4+ T cell subset
Garrison et al., Oncogene 2009
:
Here, we investigated the role of TRAF2 in
c-IAP2/MALT1 induced
NF-kappaB activation ... Studies of
c-IAP2/MALT1 BIR1 mutant ( E47A/R48A ) that fails to
activate NF-kappaB showed loss of TRAF2 binding, but retention of TRAF6 binding, suggesting that interaction of c-IAP2/MALT1 with TRAF6 is insufficient for NF-kappaB induction ... Comparisons of the bioactivity of intact c-IAP2/MALT1 oncoprotein and BIR1 E47A/R48A c-IAP2/MALT1 mutant that can not bind TRAF2 in a lymphoid cell line provided evidence that TRAF2 interaction is critical for
c-IAP2/MALT1 mediated
increases in the
NF-kappaB activity, increased expression of endogenous NF-kappaB target genes ( c-FLIP, TRAF1 ), and resistance to apoptosis