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CHUK — MALT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database BCR signaling pathway: IKK complex complex (CHUK-IKBKB-IKBKG) → CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7) (modification, collaborate)
  
• NCI Pathway Database BCR signaling pathway: CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7) → IKK alpha (CHUK) (modification, activates)
• Reactome Reaction: CHUK → MALT1 (reaction) Wang et al., Nature 2001, Zhou et al., Nature 2004, Shinohara et al., J Exp Med 2005, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
• Reactome Reaction: CHUK → MALT1 (indirect_complex) Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Shinohara et al., Immunol Rev 2009
• WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection: Complex of MALT1-CARD11-BCL10 → Complex of IKBKG-IKBKB-CHUK (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM CASP8-CHUK-IKBKB-MALT1-BCL10 complex: CASP8-CHUK-IKBKB-MALT1-BCL10 complex complex (BCL10-CASP8-CHUK-IKBKB-MALT1) Su et al., Science 2005
• IRef Corum Interaction: Complex of IKBKB-CHUK-BCL10-CASP8-MALT1 (association, coimmunoprecipitation) Su et al., Science 2005

Text-mined interactions from Literome

Ruland et al., Immunity 2003 (Lymphoma, B-Cell, Marginal Zone) : Malt1 operates downstream of Bcl10, controls the catalytic activity of the canonical IKK complex , and regulates the signaling of Jnk and p38 MAP kinases
Patke et al., Curr Opin Immunol 2004 : BCR signaling leads to activation of the inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MALT1 , whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Sun et al., Mol Cell 2004 (Lymphoma, B-Cell, Marginal Zone) : RNAi mediated silencing of MALT1 , TAK1, TRAF6, and TRAF2 suppressed TCR dependent IKK activation and interleukin-2 production in T cells ... Strikingly, only these oligomeric forms of BCL10 and MALT1 can activate IKK in vitro
Lynch et al., Mol Interv 2004 : Overexpression of MALT1, as observed in a subset of lymphoma patients, leads to the potent activation of NF-kappaB, suggesting that MALT1 might stimulate ( directly or indirectly ) the kinase complex [ IKK , inhibitor of NF-kappaB (IkappaB) kinase ] responsible for activating cytoplasmic NF-kappaB for translocation into the nucleus
Ho et al., Blood 2005 (Lymphoma, B-Cell...) : API2-MALT1 and exogenous MALT1 increased constitutive NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation