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LEP — NOTCH1

Text-mined interactions from Literome

Knight et al., Endocr Relat Cancer 2011 (Breast Neoplasms) : Leptin induced transactivation of epidermal growth factor receptor (EGFR) is involved in leptin mediated Notch1 and survivin upregulation, demonstrating a novel upstream role of leptin-EGFR-Notch1 axis
Guo et al., PloS one 2011 (Mammary Neoplasms, Animal) : Remarkably, leptin up-regulated Notch1-4/JAG1/Dll-4 , Notch target genes : Hey2 and survivin, together with IL-1 and VEGF/VEGFR-2 ... In addition, blockade of IL-1R tI inhibited leptin induced Notch , Hey2 and survivin as well as VEGF/VEGFR-2 expression ... These data suggest leptin is an inducer of Notch ( expression/activation ) and IL-1 signaling modulates leptin effects on Notch and VEGF/VEGFR-2