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NOS2 — PIK3R1

Text-mined interactions from Literome

Kristof et al., J Biol Chem 2003 (Inflammation) : The role of mTOR and PI3K in the activation of human inducible nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells
Liu et al., Circulation 2003 (MAP Kinase Signaling System) : In endothelial cells, aldosterone caused a phosphatidylinositol 3-kinase (PI3K) dependent increase in nitric oxide synthase activity as well as PI3K dependent activation of extracellular signal regulated kinase 1/2 and p70 S6 kinase
Kim et al., J Immunol 2004 : Like TGF-beta1, the PI3K inhibitor LY294002 blocked iNOS expression and death in cultured microglial cells
Jia et al., J Biol Chem 2004 : VEGF-D induced strong but more transient phosphatidylinositol 3-kinase (PI3K) mediated Akt activation and increased PI3K dependent endothelial nitric-oxide synthase phosphorylation and cell survival more weakly
Kao et al., Immunology 2005 : Tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ), PI3K inhibitors ( wortmannin and LY 294002 ), and a p38 MAPK inhibitor ( SB 203580 ) attenuated LTA induced iNOS expression and NO release in concentration dependent manners
Sun et al., Toxicol Appl Pharmacol 2006 : Serine 1179 phosphorylation of endothelial nitric oxide synthase caused by 2,4,6-trinitrotoluene through PI3K/Akt signaling in endothelial cells
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : Taken together, these results show that acacetin down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Liu et al., Biochim Biophys Acta 2007 (MAP Kinase Signaling System) : We propose that the inhibition of PI(3)K by wortmannin in mouse macrophages enhances the PI-PLC downstream signals, and subsequently increases the LPS induction of iNOS expression independently of Akt pathway
Pan et al., J Agric Food Chem 2008 : Taken together, these results show that pterostilbene down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK
Chern et al., Planta Med 2011 (Cerebral Infarction...) : Andrographolide inhibits PI3K/AKT dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Wang et al., J Cell Physiol 2011 : Taken together, these results suggested that in astrocytes, activation of NF-?B by ET ( B ) -dependent c-Src, PI3K/Akt , and p42/p44 MAPK signalings is necessary for ET-1 induced iNOS gene up-regulation
Xia et al., Mol Cell Biochem 2012 (Asthma...) : We investigated the effects of PI3K inhibitor wortmannin on iNOS expression in bronchiole epithelial cells and NO, IL-4 and IFN-? levels in lung tissues of asthmatic rat model, which was prepared by 10 % OVA solution sensitization and 1 % OVA aerosol challenge ... PI3K inhibitor wortmannin could lead to reduced iNOS expression and NO production, therefore inhibiting airway inflammatory responses
Tsai et al., Int Immunopharmacol 2012 : Suppression of PI3K expression by small interfering ( si ) RNA exhibited no effect on LPS/IFN-? stimulated NO production or iNOS protein expression in MES-13 cells
Zhang et al., Shock 2013 : A specific PI3K inhibitor, LY294002, attenuated the inhibition of nitrite production and iNOS expression produced by overexpressing a liver-specific Epac2 ( LEpac2 )