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IL13 — MUC5AC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MUC5AC
→
IL13
(increases)
Deshmukh et al., Am J Respir Crit Care Med 2005*
Evidence: Multiple agents, including cigarette smoke (15), activated eosinophils (16), interleukin-13 (17), neutrophil elastase (18), Pseudomonas aeruginosa (19), and phorbol 12-myristate 13- acetate (PMA) (20) increase MUC5AC in airway epithelial cells (NCI-H292)...
Text-mined interactions from Literome
Kibe et al., Am J Respir Crit Care Med 2003
(Eosinophilia...) :
Treatment with dexamethasone inhibited eotaxin expression and completely abolished eosinophil accumulation, but it did not affect AHR,
MUC5AC overexpression, or goblet cell hyperplasia
induced by
IL-13
Liu et al., Zhonghua Jie He He Hu Xi Za Zhi 2004
(Asthma...) :
[
Effects of
interleukin-13 on the gob-5 and
MUC5AC expression in lungs of a murine asthmatic model ]
Liu et al., J Huazhong Univ Sci Technolog Med Sci 2004
:
Effects of glucocorticoid on
IL-13 induced
Muc5ac expression in airways of mice ... To study the effects of glucocorticoid on the
IL-13 induced
Muc5ac expression in airways of mice, and investigate its role in mucus secretion of airways, 24 pathogen-free BALB/c mice were randomly divided into 3 groups
Yasuo et al., Respiration 2006
(Hyperplasia) :
However, the relationship between human calcium activated chloride channel-1 ( hCLCA1 ) and
MUC5AC induced by
IL-13 in vitro has not been fully investigated ...
IL-13 might
induce the expression of
MUC5AC and hCLCA1 gene and protein in well differentiated NHBE cells
Fujisawa et al., Respirology 2008
(Metaplasia) :
Cycloheximide also diminished activation of p38 MAPK and
induction of
MUC5AC mRNA expression by
IL-13 ... The p38 MAPK pathway is involved in
IL-13 induced mucous cell metaplasia and
MUC5AC mRNA regulation in mTEC
Malavia et al., Respir Res 2008
(Pulmonary Fibrosis) :
IL-13 induced increasing levels of
MUC5AC protein, and TGF-beta2, while decreasing beta-Tubulin IV at day 22 and 28 in the NHBE
Zhao et al., Am J Respir Crit Care Med 2009
(Asthma) :
Interleukin-13 induced
MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells ... Inhibition of 15LO1 suppressed 15-HETE-PE and decreased
MUC5AC expression in the
presence of
IL-13 stimulation ...
IL-13 induction of 15-HETE-PE
enhances MUC5AC expression in human airway epithelial cells
Kono et al., Pulm Pharmacol Ther 2010
(Asthma) :
These results suggest that SphK1 is involved in
MUC5AC production
induced by
IL-13 upstream of ERK1/2 phosphorylation, and independent of STAT6 phosphorylation
Yadav et al., PloS one 2010
(Metaplasia) :
Further,
IL-13 significantly
increased the expression of
Mucin5AC at mRNA and protein levels ... AR inhibition also decreased
IL-13 induced expression of
Muc5AC , Muc5B, and SPDEF, and phosphorylation of JAK-1, ERK1/2 and STAT-6
Yu et al., Cell communication & adhesion 2010
:
Their results showed that specific knockdown of SPDEF reduced
IL-13 induced
MUC5AC expression in human airway epithelial cells ... The authors also demonstrated that the repression of STAT6 inhibited expression of SPDEF and
MUC5AC induced by
IL-13 ... These results show that SPDEF plays a critical role in regulating a transcriptional network mediating
IL-13 induced
MUC5AC synthesis dependent on STAT6
Tanabe et al., Am J Respir Cell Mol Biol 2011
(Hyperplasia...) :
Clarithromycin also dose-dependently decreased
MUC5AC mRNA expression
induced by
IL-13 ( P < 0.001 ), and, at 24 µg/ml, clarithromycin significantly attenuated the amount of MUC5AC protein in cell supernatants ( P < 0.01 )
Tang et al., American journal of rhinology & allergy 2012
(Rhinitis, Allergic, Perennial...) :
Both
IL-13 and IL-17A significantly
promoted MUC5AC mRNA expression in HNECs, and FP treatment was able to significantly inhibit MUC5AC mRNA expression in HNECs induced by IL-13 but not for that induced by IL-17A
Wu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012
:
[ Effects of dexamethasone on
IL-13 induced mCLCA3 and
Muc5ac expressions in nasal mucosa of rats ] ... To study the effects of dexamethasone on the
IL-13 induced mCLCA3 and
Muc5ac expressions in nasal mucosa of rats, and the role in mucus secretion of allergic rhinitis
Harrop et al., Exp Lung Res 2013
:
This effect was confirmed by using mtCC1-2 cells where addition of TGF-ß ( 2 ) reduced the ability of
IL-13/EGF to
induce Muc5ac promoter expression in wild-type cells ; however, this decrease was absent in mutant promoter transfected cells
Mata et al., PloS one 2013
(Metaplasia...) :
RNO inhibited RSV infection of WD-HBE, prevented the loss of ciliated cells and markers, reduced the increase of
MUC5AC and CLCA1 and
inhibited the increase of
IL-13 , IL-6, IL-8, TNFa and ICAM-1