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PARP1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PARP1 — TP53 (physical association, affinity chromatography technology) Vaziri et al., EMBO J 1997*
• IRef Biogrid Interaction: PARP1 — TP53 (direct interaction, pull down) Vaziri et al., EMBO J 1997*
• IRef Biogrid Interaction: PARP1 — TP53 (colocalization, imaging technique) Bursać et al., Proc Natl Acad Sci U S A 2012
• IRef Biogrid Interaction: PARP1 — TP53 (direct interaction, pull down) Wesierska-Gadek et al., J Cell Biochem 2003*
• IRef Biogrid Interaction: PARP1 — TP53 (direct interaction, pull down) Simbulan-Rosenthal et al., Oncogene 2003*
• IRef Biogrid Interaction: PARP1 — TP53 (direct interaction, far western blotting) Malanga et al., J Biol Chem 1998*
• IRef Biogrid Interaction: PARP1 — TP53 (physical association, affinity chromatography technology) Gueven et al., Hum Mol Genet 2004*
• IRef Dip Interaction: PARP1 — TP53 (physical association, affinity chromatography technology) Vaziri et al., EMBO J 1997*
• IRef Dip Interaction: PARP1 — TP53 (physical association, coimmunoprecipitation) Vaziri et al., EMBO J 1997*
• IRef Hprd Interaction: TP53 — PARP1 (in vivo) Wesierska-Gadek et al., J Cell Biochem 2003*, Simbulan-Rosenthal et al., Oncogene 2003*, Malanga et al., J Biol Chem 1998*
• IRef Hprd Interaction: TP53 — PARP1 (in vitro) Wesierska-Gadek et al., J Cell Biochem 2003*, Simbulan-Rosenthal et al., Oncogene 2003*, Malanga et al., J Biol Chem 1998*
• IRef Intact Interaction: Complex of 25 proteins (association, anti bait coimmunoprecipitation) Gueven et al., Hum Mol Genet 2004*
• IRef Intact Interaction: Complex of NCL-APTX-PARP1-TP53-XRCC1 (association, pull down) Gueven et al., Hum Mol Genet 2004*
• IRef Intact Interaction: Complex of TP53-APTX-PARP1 (association, pull down) Gueven et al., Hum Mol Genet 2004*
• IRef Intact Interaction: PARP1 — TP53 (physical association, coimmunoprecipitation) Wesierska-Gadek et al., J Cell Biochem 2003*
• IRef Intact Interaction: PARP1 — TP53 (direct interaction, pull down) Wesierska-Gadek et al., J Cell Biochem 2003*
• IRef Intact Interaction: PARP1 — TP53 (direct interaction, anti bait coimmunoprecipitation) Simbulan-Rosenthal et al., Oncogene 2003*
• IRef Ophid Interaction: PARP1 — TP53 (aggregation, confirmational text mining) Malanga et al., J Biol Chem 1998*
• IRef Ophid Interaction: PARP1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Mandir et al., J Neurochem 2002 (Disease Models, Animal...) : p53 is a target of the nuclear enzyme Poly ( ADP-ribose ) polymerase ( PARP ), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) -induced neurotoxicity
Wieler et al., J Biol Chem 2003 : To investigate the role of PARP-1 in the p53 response to ionizing radiation in human cells, PARP-1 function was disrupted in wild-type p53 expressing MCF-7 and BJ/TERT cells using two strategies : chemical inhibition with 1,5-dihydroxyisoquinoline, and trans-dominant inhibition by overexpression of the PARP-1 DNA binding domain
Watanabe et al., Biochem Biophys Res Commun 2004 : Furthermore, in vitro, PARP-1 inhibited phosphorylation of p53 on serine 15 and ( 32 ) P-incorporation into p53 by ATM in a DNA dependent manner
Fang et al., Oncogene 2006 : Given that PARP-1 mediates DNA damage responses and regulates the activity of p53 , our studies suggest that there exists a cross-talk between the spindle checkpoint and the DNA damage checkpoint and that BubR1 may play an important role in mediating the cross-talk
Baumann et al., Nucleic Acids Res 2006 : Our data further indicate that PARP-1 , probably through topoisomerase I interactions rather than poly ( ADP-ribosyl ) ation, prevents p53 from stimulating spontaneous HR on chromosomes via topoisomerase I activity
Zhang et al., Clin Cancer Res 2006 (Melanoma...) : This was characterized by lack of DNA fragmentation, delayed externalization of phosphatidylserine, caspase and p53 independence, and severe mitochondrial disruption, and was preceded by poly ( ADP ) ribose polymerase ( PARP ) activation and depletion of intracellular ATP, indicative of necrotic cell death
Canner et al., Br J Cancer 2009 (Rhabdomyosarcoma, Alveolar...) : However, RD2 and RH30 RMS cells, as well as human normal skeletal muscle cells, showed a minimal increase in p53 signalling and no induction of cleaved PARP and caspase-3
Lee et al., Oncol Rep 2010 (Adenocarcinoma...) : In this study, we examined the chemoresistance to 5-Fluorouracil ( 5-FU ) using MCF-7 breast cancer MTS. 5-FU ( 400 microM ) induced apoptosis in MCF-7 cell monolayer as determined by HO/PI staining, PARP cleavage, p53 induction , Bax induction, and Bcl-2 down-regulation
Matsushima et al., Biochem Biophys Res Commun 2011 : These results show that Nutlin induces the proteasomal degradation of Parp1 in a p53 dependent manner
Ferraz da Costa et al., PloS one 2012 (Breast Neoplasms...) : The resveratrol induced cytotoxicity in these cells was partially mediated by p53 and involved the activation of caspases 9 and 7 and the cleavage of PARP
Wesierska-Gadek et al., Cancer Res 1999 : Here, we have investigated whether PARP deficiency may affect the expression and regulation of wild-type ( wt ) p53
Simbulan-Rosenthal et al., Biochem Biophys Res Commun 1998 (Burkitt Lymphoma) : The role of poly ( ADP-ribose ) polymerase ( PARP ), an abundant nuclear enzyme activated by DNA strand breaks, in the p53 response to y-irradiation was investigated in Burkitt 's lymphoma AG876 cells stably transfected with an inducible PARP antisense construct