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RAC1 — TSC1
Text-mined interactions from Literome
Goncharova et al., J Cell Biol 2004
:
Our data indicate that
TSC1 inhibits
Rac1 and TSC2 blocks this activity of TSC1 ... Because
TSC1 and TSC2
regulate Rho and
Rac1 , whose activities are interconnected in a reciprocal fashion, loss of either TSC1 or TSC2 function may result in the deregulation of cell motility and adhesion, which are associated with the pathobiology of TSC and LAM
Ohsawa et al., PloS one 2013
(Cell Transformation, Neoplastic...) :
Recent studies have suggested that
TSC1 and TSC2 also
regulate the activities of
Rac1 and Rho, members of the Rho family of small GTPases, and thereby influence the ensuing actin cytoskeletal organization at focal adhesions