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FLNA — RELA
Text-mined interactions from Literome
Mashima et al., J Biol Chem 2005
:
The forced expression of
FLN29 in macrophage-like RAW cells
resulted in the suppression of TLR mediated
NF-kappaB and mitogen activated protein kinase activation, while a reduced expression of FLN29 by small interfering RNA partly cancelled the down-regulation of LPS signaling
Hayashi et al., J Immunol 2006
:
Depletion of
FLNa by RNA interference did not affect TCR induced early tyrosine phosphorylation or actin polymerization but, nevertheless,
resulted in impaired IL-2 expression by human primary T cells and reduced activation of
NF-kappaB , AP-1, and NFAT reporter genes in transfected T cells
Sanada et al., J Biol Chem 2008
:
Forced expression of
FLN29 inhibited the IPS-1 dependent activation of both
NF-kappaB and IRF3