◀ Back to NOX1
MMP9 — NOX1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Abe et al., Life Sci 2006
:
Diphenylene iodonium, an inhibitor of
NADPH oxidase ,
had a similar effect on
MMP-9 activity
Spallarossa et al., Cardiovasc Res 2006
(MAP Kinase Signaling System) :
Inhibition of
NAD ( P ) H oxidase attenuates the increase in MMP-2, but
augments the doxorubicin induced increase in
MMP-9
Cook-Mills et al., Cell Mol Biol Incl Cyto Enzymol 2006
:
The endothelial cell NADPH oxidase and endothelial cell
MMP activities are
required for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS, by pharmacologic or antisense inhibition of
NADPH oxidase and by pharmacologic inhibition of endothelial cell MMPs
San José et al., Free Radic Biol Med 2009
:
Insulin mediated
NADPH oxidase activation
stimulated MMP-9 activation in monocytes and cell proliferation in macrophages
Jagadeesha et al., Cardiovasc Res 2012
(MAP Kinase Signaling System) :
The Nox1
NADPH oxidase signals through EGFR to
activate MMP-9 and promote the shedding of N-cadherin, thereby contributing to SMC migration
Xu et al., J Vasc Res 2012
(Neointima) :
Following vascular injury, the increased expression of
Nox1 in SMCs within the neointima
initiates redox dependent phosphorylation of ERK1/2 and subsequent
MMP-9 activation
Hsieh et al., Journal of neuroinflammation 2012
:
These results demonstrated that in RBA-1 cells, activation of ATF2/AP-1 by the PKC ( a ) -mediated
Nox ( 2 ) /ROS signals is
essential for upregulation of
MMP-9 and cell migration enhanced by LTA
Lin et al., Cell communication and signaling : CCS 2012
:
These results demonstrated that in RBA-1 cells, activation of AP-1 ( c-Fos/c-Jun ) by the PKC-a mediated
Nox2/ROS signals is
essential for up-regulation of
MMP-9 and cell migration enhanced by BK
Kuo et al., Int J Immunopathol Pharmacol 2013
(Anoxia...) :
KMUP-1 protects liver from I/R-injury and hypoxic hepatocytes from apoptosis associated free radical generation and pro-inflammation by restoring/increasing NO/cGMP/PPAR-gamma, reducing
ROS/Nox2 and
inhibiting ROCKII/MMP-9