◀ Back to MYC
MYC — TRRAP
Pathways - manually collected, often from reviews:
-
NCI Pathway Database C-MYC pathway:
TRRAP/TIP60 complex (TRRAP-KAT5)
→
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
TRRAP/TIP60 complex (TRRAP-KAT5)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
BAF53 (ACTL6A)
→
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
TIP49A/TIP49B complex (RUVBL1-RUVBL2)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
CAD (CAD)
(transcription, activates)
Eberhardy et al., J Biol Chem 2001, Frank et al., EMBO Rep 2003, Boyd et al., Proc Natl Acad Sci U S A 1998, Bush et al., Genes Dev 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
NME1 (NME1)
(transcription, activates)
Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Greenberg et al., Oncogene 1999, Faiola et al., Mol Cell Biol 2005, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database C-MYC pathway:
STAF65G (SUPT7L)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF10 (TAF10)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF12 (TAF12)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
SPT3 (SUPT3H)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max complex (MYC-MAX)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max complex (MYC-MAX)
→
TRRAP/GCN5 complex (TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF9 (TAF9)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
TRRAP/GCN5 complex (TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
PTMA (PTMA)
(transcription, activates)
Frank et al., EMBO Rep 2003, Eilers et al., EMBO J 1991, Gaubatz et al., Mol Cell Biol 1994
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
Nucleolin (NCL)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Bouchard et al., EMBO J 1999, Bouchard et al., Genes Dev 2001, Vervoorts et al., EMBO Rep 2003
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
GPAT (GPAM)
(transcription, activates)
Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
HSP60 (HSPD1)
(transcription, activates)
Frank et al., Genes Dev 2001, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
HSP60 (HSPD1)
(transcription, activates)
Frank et al., Genes Dev 2001, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
TRRAP (TRRAP)
→
MYC/Max complex (MYC-MAX)
(rRNA transcription, activates)
Poortinga et al., EMBO J 2004*, Arabi et al., Nat Cell Biol 2005*, Grandori et al., Nat Cell Biol 2005*
Evidence: mutant phenotype, assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MYC
—
TRRAP
Liu et al., J Biol Chem 2003
-
IRef Bind_translation Interaction:
MYC
—
TRRAP
(affinity chromatography technology)
Liu et al., J Biol Chem 2003
-
IRef Bind_translation Interaction:
MYC
—
TRRAP
(coimmunoprecipitation)
Liu et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
McMahon et al., Mol Cell Biol 2000
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(direct interaction, pull down)
McMahon et al., Cell 1998
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
Park et al., Mol Cell Biol 2002
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
Brès et al., Mol Cell 2009
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
Cowling et al., Mol Cell Biol 2006*
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(colocalization, imaging technique)
Frank et al., Genes Dev 2001
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
Kim et al., Cell 2010
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(physical association, affinity chromatography technology)
Liu et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
MYC
—
TRRAP
(association, biochemical)
Liu et al., J Biol Chem 2003
-
MIPS CORUM cMYC-ATPase-helicase complex:
cMYC-ATPase-helicase complex complex (ACTL6A-MYC-RUVBL1-RUVBL2-TRRAP)
Wood et al., Mol Cell 2000
-
MIPS CORUM c-MYC-ATPase-helicase complex:
c-MYC-ATPase-helicase complex complex (ACTL6A-MYC-RUVBL1-RUVBL2-TRRAP)
Park et al., Mol Cell Biol 2002
-
IRef Corum Interaction:
Complex of 16 proteins
(association, anti bait coimmunoprecipitation)
Park et al., Mol Cell Biol 2002
-
IRef Dip Interaction:
MYC
—
TRRAP
(physical association, coimmunoprecipitation)
McMahon et al., Cell 1998
-
IRef Dip Interaction:
MYC
—
TRRAP
(physical association, coimmunoprecipitation)
Liu et al., J Biol Chem 2003
-
IRef Hprd Interaction:
TRRAP
—
MYC
(in vivo)
McMahon et al., Cell 1998
-
IRef Hprd Interaction:
TRRAP
—
MYC
(in vitro)
McMahon et al., Cell 1998
-
IRef Intact Interaction:
MYC
—
TRRAP
(physical association, anti bait coimmunoprecipitation)
Ewing et al., Molecular systems biology 2007
-
IRef Intact Interaction:
MYC
—
TRRAP
(physical association, anti tag coimmunoprecipitation)
McMahon et al., Cell 1998
-
IRef Intact Interaction:
MYC
—
TRRAP
(physical association, coimmunoprecipitation)
McMahon et al., Cell 1998
-
IRef Intact Interaction:
Complex of 222 proteins
(association, tandem affinity purification)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Ophid Interaction:
MYC
—
TRRAP
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Bouchard et al., Genes Dev 2001
:
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network :
Myc dependent
TRRAP recruitment and histone acetylation at the cyclin D2 promoter ... Binding of
Myc induces cyclin D2 expression and histone acetylation at a single nucleosome in a
MycBoxII/TRRAP dependent manner
Liu et al., J Biol Chem 2003
:
Myc induces
TRRAP recruitment and histone hyperacetylation at specific Myc activated genes in vivo