Gene interactions and pathways from curated databases and text-mining

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Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ohlsson et al., Eur J Endocrinol 2009 : Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the estrogen receptor (ER)alpha and activation of the androgen receptor result in a stimulatory effect on both the cortical and trabecular bone mass in males
Peters et al., Cancer Res 2009 (Breast Neoplasms...) : Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer
Mullany et al., Am J Physiol Gastrointest Liver Physiol 2010 : Previous reports have shown that cyclin D1 can directly enhance estrogen receptor activity and inhibit androgen receptor activity in a ligand independent manner and thus may play an important role in hormone-responsive malignancies
Zhao et al., Exp Clin Endocrinol 1993 : Estrogen receptor was induced in epithelium and stroma in estrogenized animals whereas the androgen receptor was reduced in experimental specimens